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Citation: Miao Fang-Ming, Su Hua-Qing, Wang Jin-Ling, Li Ai-Xiu. Pharmacophore Model of ALS Inhibitors by DISCO Method[J]. Acta Physico-Chimica Sinica, ;2000, 16(10): 926-931. doi: 10.3866/PKU.WHXB20001011 shu

Pharmacophore Model of ALS Inhibitors by DISCO Method

1.
Institute of Crystallography of Tianjin Normal University,Tianjin 300074

Received Date: 8 February 2000
Available Online: 15 October 2000

In this paper Pharmacophore Models of the interaction of four varieties of ALS inhibitors by distance comparison (DISCO) method with unknown three-dimensional structure of the receptor are reported. The Model not only conforms to our research requirement, but also helps to find a lot of unexpected biological information, which provides a theoretical guidance for the further design of new and more active ALS inhibitory herbicides and the active cavity simulation of its receptors.
- ALS inhibitors,
- DISCO,
- Herbicide,
- Pharmacophore Model
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