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Citation: Han ng-She, Yan Long-Fei, Wang Bao-Huai, Zhang You-Min. Microcalorimetric Studies of the Tubulin Polymerization and the Interaxtion between Tubuin and Taxol[J]. Acta Physico-Chimica Sinica, ;1997, 13(11): 969-973. doi: 10.3866/PKU.WHXB19971103 shu

Microcalorimetric Studies of the Tubulin Polymerization and the Interaxtion between Tubuin and Taxol

1.
College of Biological Science,China Agricultural University,Beijing 100094

Received Date: 25 August 1997
Available Online: 15 November 1997

The heat properties of porcine brain tubulin polymerization and the interaction of the tubulin with taxol were studied with an MS-80 Calvet Microcalorimeter .The heat vibration occured within 1.5h when tubulin solution was diluted from a highe r concentration to a lower one. The thermodynamic parameters of tubulin polymerization at 303.15K and 298. 15K were measured in 10μmol•L-1 tubulin solution, its △H's were 22kJ•mol-1 and 29.3kJ•mol-1，respectively.Adding different concentration of taxol in the course of polymerization of tubulin give rise to a great change in △H. The time of taxol combining to polymerized microtubule was about one minute after the beginning of the reaction. The mechanism of tubulin polymerization under different conditions was discussed.
- Tubulin,
- Taxol,
- Thermogram
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