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Citation: Kan Jin-Qing, Mu Shao-Lin. Study on Inhibition of Xanthine Oxidase by Umbelliferone[J]. Acta Physico-Chimica Sinica, ;1997, 13(07): 650-654. doi: 10.3866/PKU.WHXB19970716 shu

Study on Inhibition of Xanthine Oxidase by Umbelliferone

1.
Department of Chemistry,Teacher's College,Yangzhou University,Yangzhou 225002

Received Date: 16 December 1996
Available Online: 15 July 1997

The investigation on inhibition of xanthine oxidase by umbelliferone was carried out using a polyaniline-xanthine oxidase electrode. The experimental results indicated significant inhibition caused by umbelliferone. The apparent Michaelis-Menten constant (K'm) and the maximum rate (im) of the immobilized xanthine oxidase were both affected by umbelliferone. This indicated that umbelliferone acts as a mixed type of inhibitor of xanthine oxidase. The optimal pH of the immobilized enzyme was hardly affected by umbelliferone; The response current increases with increasing potential in the potential range 0.55~0.68V.
- Polyaniline,
- Xanthine oxidase,
- Umbelliferone,
- Inhibition
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