Citation: Zhibei Qu, Changxin Wang, Lei Li, Jiaze Li, Jun Zhang. Organoid-on-a-Chip for Drug Screening and the Inherent Biochemistry Principles[J]. University Chemistry, ;2024, 39(7): 278-286. doi: 10.3866/PKU.DXHX202311039 shu

Organoid-on-a-Chip for Drug Screening and the Inherent Biochemistry Principles

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China

Received Date: 12 November 2023
Revised Date: 24 November 2023

Organoid-on-a-chip technology emerges as a groundbreaking interdisciplinary innovation of the 21st century, cultivating human cells in three-dimensions ex vivo to form organoids. These organoids replicate human physiological and pathological conditions as well as functions akin to human organs. Integratable with electronic chips, this technology finds extensive applications in drug screening, safety evaluation, personalized medicine, in vitro diagnosis. As a recent avant-grade technological advancement, organoid-on-a-chip demonstrates several benefits over traditional cell-based animal testing methods used for drug screening, such as lower costs, better animal welfare, higher precision, and wider applicability. This positions it at the forefront of future drug screening and safety evaluation methodologies. The use of organoid chips in drug screening encapsulates a plethora of inherent biochemical principles. Incorporating organoid-on-chip related knowledge into university curricula plays a significant role in enabling medical and pharmaceutical students to stay abreast of the forefront in drug development and to grasp biochemical concepts in a more systematic manner. Therefore, this paper begins with the concept of organoid chips, exploring their design, principles, and applications in drug screening, while anticipating their future developments. Simultaneously, it focuses on the multidisciplinary interdisciplinary characteristics of organoid chips in fields, such as cell biology, medicinal chemistry, biochemistry, and electronic information science, analyzing the inherent biochemical principles. In line with this, the paper proposes an 8 lecture-course design for the Biochemistry curriculum, aiming to meet the evolving educational demands for nurturing innovative talents in the pharmaceutical sector.
- Organoid-on-a-chip,
- Drug screening,
- Organ culture,
- Biochemistry education
1. [1]
2. [2]
3. [3]
4. [4]
  Zhang, B. Y.; Korolj, A.; Lai, B. F. L; Radisic, M. Nat. Rev. Mater. 2018, 3 (8), 257.
5. [5]
6. [6]
7. [7]
8. [8]
  Vlachogiannis, G.; Hedayat, S.; Vatsiou, A.; Jamin, Y.; Fernández-Mateos, J.; Khan, K.; Lampis, A.; Eason, K.; Huntingford, L.; Burke, R.; et al. Science 2018, 359 (6378), 920.
9. [9]
10. [10]
11. [11]
12. [12]
  Cho, A.-N.; Jin, Y.; An, Y.; Kim, J.; Choi, Y. S.; Lee, J. S.; Kim, J.; Choi, W.-Y.; Koo, D.-J.; Yu, W.; et al. Nat. Commun. 2021, 12, 4730.
13. [13]
  Wang, Y.; Wang, H.; Deng, P.; Tao, T.; Liu, H.; Wu, S.; Chen, W.; Qin, J. ACS Biomater. Sci. Eng. 2020, 6(10), 5734.
14. [14]
  Schuster, B.; Junkin, M.; Kashaf, S. S.; Romero-Calvo, I.; Kirby, K.; Matthews, J.; Weber, C. R.; Rzhetsky, A.; White, K. P.; Tay, S. Nat. Commun. 2020, 11, 5271.
15. [15]
  Rajan, S. A. P.; Aleman, J.; Wan, M.; Zarandi, P. N.; Nzou, G.; Murphy, S.; Bishop, C. E.; Sadri-Ardekani, H.; Shupe, T.; Atala, A.; et al. Acta Biomater. 2020, 106, 124.
16. [16]
17. [17]
18. [18]
19. [19]
20. [20]
21. [21]
22. [22]
23. [23]
24. [24]
25. [25]
26. [26]
27. [27]
28. [28]
29. [29]
30. [30]
31. [31]
32. [32]
33. [33]
1. [1]
  Peng Zhan . Practice and Reflection in Training Medicinal Chemistry Graduate Students. University Chemistry, 2024, 39(6): 112-121. doi: 10.3866/PKU.DXHX202402022
2. [2]
  Yihui Song , Shangshang Qin , Kai Wu , Chengyun Jin , Bin Yu . 生物化学在高水平创新型药学人才培养中的交叉融合应用——以去甲基化酶LSD1抑制剂的活性评价为例. University Chemistry, 2025, 40(6): 341-352. doi: 10.12461/PKU.DXHX202406018
3. [3]
  Peihong Fan , Hongxiang Lou . 研究生高等天然药物化学课程的教学改革探索——导学互促式混合课堂教学与自主学习能力培养. University Chemistry, 2025, 40(6): 16-21. doi: 10.12461/PKU.DXHX202407078
4. [4]
  Ying Zhang , Fang Ge , Zhimin Luo . AI-Driven Biochemical Teaching Research: Predicting the Functional Effects of Gene Mutations. University Chemistry, 2025, 40(3): 277-284. doi: 10.12461/PKU.DXHX202412104
5. [5]
  Dongyan Tang , Yanqiu Jiang , Su'e Hao , Yunchen Du , Lizhu Zhang , Zhigang Liu . 融合优势资源与聚焦多元培养的非化类大学化学一流课程建设. University Chemistry, 2025, 40(6): 71-76. doi: 10.12461/PKU.DXHX202406062
6. [6]
  Liangyu Gong , Yongsheng Niu , Xiuzhong Wang , Lihua Lu , Lubin Xu , Shuaishuai Li , Jie Wang . “农科教”融合培养“农化”背景丰富的化学类复合应用型人才路径探索与实践. University Chemistry, 2025, 40(8): 330-337. doi: 10.12461/PKU.DXHX202410011
7. [7]
  Xiaoxuan Yu , Wukun Liu . Practice of Ideological and Political Education in Medicinal Chemistry for Pharmacy Administration Major: A Case Study on the Discovery of Cisplatin’s Anticancer Function. University Chemistry, 2025, 40(4): 408-414. doi: 10.12461/PKU.DXHX202405200
8. [8]
  Dapeng Liu , Fang Wang , Jingbin Zeng . Exploration on College Chemistry Teaching Focused on Cultivation of Scientific Research Ability. University Chemistry, 2024, 39(8): 126-131. doi: 10.3866/PKU.DXHX202401034
9. [9]
  Jiamin Zhang , Zhen Fan , Jianzhong Du . Integrated Teaching Method Combining Domestic and International Perspectives: A Case Study on Cultivating Innovative Talents in Polymeric Biomaterials. University Chemistry, 2025, 40(7): 156-160. doi: 10.12461/PKU.DXHX202409131
10. [10]
  Fangfang Chen , Haiming Fan , Yan Li , Yuan He . 化学生物学专业多元化人才培养导向的课程体系优化探索. University Chemistry, 2025, 40(8): 92-99. doi: 10.12461/PKU.DXHX202409108
11. [11]
  Dongcheng Liu , Xiaokun Li , Huancheng Hu , Cunji Gao , Qiong Hu , Shuting Li , Yuning Liang . Chemistry Experimental Teaching Reform for the Promotion of Training Exceptional Chemistry Teachers for Normal Schools. University Chemistry, 2024, 39(8): 1-6. doi: 10.3866/PKU.DXHX202311072
12. [12]
  Xiuya Ma , Yu Chen , Yan Zhang . Stories about Pharmaceuticals. University Chemistry, 2025, 40(7): 232-240. doi: 10.12461/PKU.DXHX202408003
13. [13]
  Jinglun Wang , Hu Zhou , Baishu Zheng , Guobin Li , Ming Yue , Zhihua Zhou . Exploration and Practice of “Four Cooperations and Four Integrations” to Cultivate Innovative Talents in Chemical Materials in Local Colleges. University Chemistry, 2024, 39(7): 93-98. doi: 10.12461/PKU.DXHX202405013
14. [14]
  Qin Tu , Anju Tao , Tongtong Ma , Jinyi Wang . Innovative Experimental Teaching of Escherichia coli Detection Based on Paper Chip. University Chemistry, 2024, 39(6): 271-277. doi: 10.3866/PKU.DXHX202309062
15. [15]
  Min Gu , Huiwen Xiong , Liling Liu , Jilie Kong , Xueen Fang . Rapid Quantitative Detection of Procalcitonin by Microfluidics: An Instrumental Analytical Chemistry Experiment. University Chemistry, 2024, 39(4): 87-93. doi: 10.3866/PKU.DXHX202310120
16. [16]
  Yecang Tang , Shan Ling , Zhen Fang . Exploration of a Hierarchical and Integration-Oriented Talent Training Model in the Demonstration Center for Experimental Chemistry Education. University Chemistry, 2024, 39(7): 188-192. doi: 10.12461/PKU.DXHX202405107
17. [17]
  Yan Li , Fei Ding , Jielun Yan , Qingyang Zhou , Zhe Wang , Yifan Shi , Jing Wang , Anna Tang . Improving Instrumental Analytical Chemistry Laboratory Teaching: Developing a Bilingual Classroom to Cultivate Innovative Talents. University Chemistry, 2025, 40(7): 83-89. doi: 10.12461/PKU.DXHX202409059
18. [18]
  Guowen Xing , Guangjian Liu , Le Chang . Five Types of Reactions of Carbonyl Oxonium Intermediates in University Organic Chemistry Teaching. University Chemistry, 2025, 40(4): 282-290. doi: 10.12461/PKU.DXHX202407058
19. [19]
  Ziheng Zhuang , Xiao Xu , Kin Shing Chan . Superdrugs for Superbugs. University Chemistry, 2024, 39(9): 128-133. doi: 10.3866/PKU.DXHX202309040
20. [20]
  Haibo Zhang , Yuwen Liu , Qiong Ding , Chi Huang , Faqiong Zhao , Jinping Zhou . The Construction of National Demonstration Center for Experimental Chemistry Education and the Practice of Top-Notch Innovative Talent Cultivation. University Chemistry, 2024, 39(7): 82-92. doi: 10.12461/PKU.DXHX202405012

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(210)
HTML views(10)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142