Citation: Zhibei Qu, Changxin Wang, Lei Li, Jiaze Li, Jun Zhang. Organoid-on-a-Chip for Drug Screening and the Inherent Biochemistry Principles[J]. University Chemistry, ;2024, 39(7): 278-286. doi: 10.3866/PKU.DXHX202311039 shu

Organoid-on-a-Chip for Drug Screening and the Inherent Biochemistry Principles

Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China

Received Date: 12 November 2023
Revised Date: 24 November 2023

Organoid-on-a-chip technology emerges as a groundbreaking interdisciplinary innovation of the 21st century, cultivating human cells in three-dimensions ex vivo to form organoids. These organoids replicate human physiological and pathological conditions as well as functions akin to human organs. Integratable with electronic chips, this technology finds extensive applications in drug screening, safety evaluation, personalized medicine, in vitro diagnosis. As a recent avant-grade technological advancement, organoid-on-a-chip demonstrates several benefits over traditional cell-based animal testing methods used for drug screening, such as lower costs, better animal welfare, higher precision, and wider applicability. This positions it at the forefront of future drug screening and safety evaluation methodologies. The use of organoid chips in drug screening encapsulates a plethora of inherent biochemical principles. Incorporating organoid-on-chip related knowledge into university curricula plays a significant role in enabling medical and pharmaceutical students to stay abreast of the forefront in drug development and to grasp biochemical concepts in a more systematic manner. Therefore, this paper begins with the concept of organoid chips, exploring their design, principles, and applications in drug screening, while anticipating their future developments. Simultaneously, it focuses on the multidisciplinary interdisciplinary characteristics of organoid chips in fields, such as cell biology, medicinal chemistry, biochemistry, and electronic information science, analyzing the inherent biochemical principles. In line with this, the paper proposes an 8 lecture-course design for the Biochemistry curriculum, aiming to meet the evolving educational demands for nurturing innovative talents in the pharmaceutical sector.
- Organoid-on-a-chip,
- Drug screening,
- Organ culture,
- Biochemistry education
1. [1]
2. [2]
3. [3]
4. [4]
  Zhang, B. Y.; Korolj, A.; Lai, B. F. L; Radisic, M. Nat. Rev. Mater. 2018, 3 (8), 257.
5. [5]
6. [6]
7. [7]
8. [8]
  Vlachogiannis, G.; Hedayat, S.; Vatsiou, A.; Jamin, Y.; Fernández-Mateos, J.; Khan, K.; Lampis, A.; Eason, K.; Huntingford, L.; Burke, R.; et al. Science 2018, 359 (6378), 920.
9. [9]
10. [10]
11. [11]
12. [12]
  Cho, A.-N.; Jin, Y.; An, Y.; Kim, J.; Choi, Y. S.; Lee, J. S.; Kim, J.; Choi, W.-Y.; Koo, D.-J.; Yu, W.; et al. Nat. Commun. 2021, 12, 4730.
13. [13]
  Wang, Y.; Wang, H.; Deng, P.; Tao, T.; Liu, H.; Wu, S.; Chen, W.; Qin, J. ACS Biomater. Sci. Eng. 2020, 6(10), 5734.
14. [14]
  Schuster, B.; Junkin, M.; Kashaf, S. S.; Romero-Calvo, I.; Kirby, K.; Matthews, J.; Weber, C. R.; Rzhetsky, A.; White, K. P.; Tay, S. Nat. Commun. 2020, 11, 5271.
15. [15]
  Rajan, S. A. P.; Aleman, J.; Wan, M.; Zarandi, P. N.; Nzou, G.; Murphy, S.; Bishop, C. E.; Sadri-Ardekani, H.; Shupe, T.; Atala, A.; et al. Acta Biomater. 2020, 106, 124.
16. [16]
17. [17]
18. [18]
19. [19]
20. [20]
21. [21]
22. [22]
23. [23]
24. [24]
25. [25]
26. [26]
27. [27]
28. [28]
29. [29]
30. [30]
31. [31]
32. [32]
33. [33]
1. [1]
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2. [2]
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