光催化氧化绿色合成医用化学发光试剂

引用本文: 马敏娜, 欧阳玉瑾, 邬源, 袁明伟, 杨丽娟. 光催化氧化绿色合成医用化学发光试剂[J]. 大学化学, 2024, 39(5): 134-143. doi: 10.3866/PKU.DXHX202310093 shu

Citation: Minna Ma, Yujin Ouyang, Yuan Wu, Mingwei Yuan, Lijuan Yang. Green Synthesis of Medical Chemiluminescence Reagents by Photocatalytic Oxidation[J]. University Chemistry, 2024, 39(5): 134-143. doi: 10.3866/PKU.DXHX202310093 shu

光催化氧化绿色合成医用化学发光试剂

云南民族大学化学与环境学院, 生物基材料绿色制备技术国家地方联合工程中心, 昆明 650500
基金项目:
国家自然科学基金项目(52163013)

摘要: 光催化氧化较传统氧化反应更具有安全可控、条件温和、绿色环保的优点，已成为化学前沿中的研究热点之一，并受到广泛关注。目前，受实验条件和设备的限制，光催化氧化反应在本科教学实验中较为缺乏。本实验利用实验室常规仪器组装出简易光反应装置，以高效低能的钠灯为光源催化氧化磷酸盐中间体，实现了1,2-二氧环乙烷类医用化学发光试剂的实验室微量化制备，丰富了光化学反应在实验教学中的应用。本实验使用的原料和试剂便宜易得，操作简便，产物收率高，实验既可实现单瓶独立操作，又可进行多瓶串联反应。本文综合考虑实验成本、实验与教学效率，以两瓶串联方式展开分组实验教学，在实现教学形式多样化的同时，培养学生合作意识，适合本科实验教学，帮助学生提高全面综合的实验操作能力，加深对自由基加成等反应机理的理解。

关键词:

English

Green Synthesis of Medical Chemiluminescence Reagents by Photocatalytic Oxidation

National and Local Joint Engineering Research Center for Green Preparation Technology of Bio-based Materials, College of Chemistry and Environment, Yunnan University for Nationalities, Kunming 650500, China
Received Date: 25 October 2023
Revised Date: 02 February 2024

Abstract: Photocatalytic oxidation, distinguished by its safety, controllability, mild conditions, and environmental friendliness compared to traditional oxidation reactions, has emerged as a prominent research focus in the forefront of chemistry, garnering widespread attention. However, its application in undergraduate teaching experiments has been limited by experimental conditions and equipment constraints. In this experiment, we devised a simple photoreaction device using conventional laboratory instruments. Employing a high-efficiency, low-energy sodium lamp as the light source to catalyze the oxidation of phosphate intermediates, we achieved the laboratory-scale synthesis of 1,2-dioxocycloethane-type medical chemiluminescence reagents, diversifying the application of photochemical reactions in experimental teaching. The materials and reagents used in this experiment are inexpensive and readily available, the operation is straightforward, and the yield of the product is high. The experiment allows for both independent single-bottle operations and the execution of multiple-bottle series reactions. Considering the experimental cost and teaching efficiency, we conducted group experimental teaching with a two-bottle series, fostering diverse teaching forms and nurturing students’ cooperative skills. This approach is well-suited for undergraduate experimental teaching, aiding students in enhancing their comprehensive experimental operational abilities and deepening their understanding of reaction mechanisms such as radical coupling.

Key words:

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光催化氧化绿色合成医用化学发光试剂

English

Green Synthesis of Medical Chemiluminescence Reagents by Photocatalytic Oxidation

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

光催化氧化绿色合成医用化学发光试剂

English

Green Synthesis of Medical Chemiluminescence Reagents by Photocatalytic Oxidation

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

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