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Citation: Zhenyu Guo, Yuhang Li, Shuai Chen, Chengjian Zhu, Jin Xie. Photoredox/Nickel-Catalyzed Synthesis of 4'-Methoxypropiophenone[J]. University Chemistry, ;2024, 39(1): 210-217. doi: 10.3866/PKU.DXHX202306046 shu

Photoredox/Nickel-Catalyzed Synthesis of 4'-Methoxypropiophenone

School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

Corresponding author: Jin Xie, xie@nju.edu.cn
Received Date: 23 June 2023

The photo-nickel synergistic catalytic reaction emerges as a promising synthetic method, offering advantages such as high yields, mild reaction conditions, and broad scope. Guided by the principles of sustainable development, we have successfully synthesized valued aromatic ketone derivatives utilizing prevalent industrial feedstocks, aromatic carboxylic acids and ethylene under mild reaction conditions. It would be the first example of photo-nickel synergistic catalyzed reaction between aromatic acids and ethylene under air atmosphere. This synthetic method features in a high efficiency utilization of resource, simple operation and easy access for the students to grasp. This approach not only bridges a knowledge gap in teaching photochemical reactions within foundational organic chemistry experiments but also holds substantial practical and pedagogical merit.
- Visible-light photocatalysis,
- nickel catalysis,
- Aryl ketones,
- Organic chemistry experiment
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