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Citation: Yicheng Luo, Yanfeng Gao, Weisheng Lin, Zhiwei Miao. Synthesis of Diethyl 2-Benzyl-3,4-dioxo-6-phenyl-9-vinyl-2-azaspiro [4.4]nonane-7,7-dicarboxylate through Palladium Catalyzed Tandem Cyclization: Introducing a Comprehensive Experiment of Organic Chemistry[J]. University Chemistry, ;2023, 38(10): 250-257. doi: 10.3866/PKU.DXHX202212063 shu

Synthesis of Diethyl 2-Benzyl-3,4-dioxo-6-phenyl-9-vinyl-2-azaspiro [4.4]nonane-7,7-dicarboxylate through Palladium Catalyzed Tandem Cyclization: Introducing a Comprehensive Experiment of Organic Chemistry

1.
State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China;
2.
Department of Ecological and Resources Engineering, Wuyi University, Wuyishan 354300, Fujian Province, China

Corresponding author: Zhiwei Miao, miaozhiwei@nankai.edu.cn
Received Date: 23 December 2022
Revised Date: 7 March 2023

The comprehensive experiment of organic chemistry is conducive to training students’ experimental skills, cultivating their innovative ability, and stimulating their independent thinking ability and research consciousness. This article presents a comprehensive organic chemistry experiment in which 2-vinylcyclopropane-1,1-diethyl diformate and 1-benzyl-4-benzylidene-2,3-pyrrolidone were used as reactants to synthesize 2-benzyl-3,4-dicarbonyl-6-phenyl-9-vinyl-2-azanone-7,7-dicarboxylate ethyl ester by palladium-catalyzed tandem cyclization reaction. ¹H NMR, ¹³C NMR and HRMS characterized the structure of the product.
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