Citation: Yanqi Du, Rujing Li, Jitong Yang, Yuan Li, Xiaoning Jin, Yong Wang. Click Construction of Cationic Chiral Supramolecular Medium for Efficient Enantioseparation of Amino Acids: Exploring and Practicing Ideological and Political Education in Chemical Experiment Curriculum[J]. University Chemistry, ;2023, 38(4): 58-67. doi: 10.3866/PKU.DXHX202210051 shu

Click Construction of Cationic Chiral Supramolecular Medium for Efficient Enantioseparation of Amino Acids: Exploring and Practicing Ideological and Political Education in Chemical Experiment Curriculum

Yanqi Du ¹ ,
Rujing Li ¹ ,
Jitong Yang ¹ ,
Yuan Li ¹ ,
Xiaoning Jin ^1,2 ,
Yong Wang ^1,2

1.
School of Science, Tianjin University, Tianjin 300354, China;
2.
National Demonstration Center for Experimental Chemistry & Chemical Engineering Education, Tianjin University, Tianjin 300354, China

Received Date: 20 October 2022

Chirality is the essential attribute of life. Molecular chirality is closely related to the fine regulation of life phenomena. The pharmacology and toxicology of drugs with different enantiomers vary significantly different. Owing to the recent advancements in the chiral drug market, the development of efficient and accurate chiral separation strategy has become critical. Aiming at the construction of new engineering subjects 2.0, the idea of “chiral separation workshop” comprehensive experiment was proposed for the first time. The chiral recognition mechanism based on intermolecular weak interaction was investigated using the click-chemical green synthesis strategy to realize the highly efficient grafting of single-positively charged cyclodextrins and the construction of positively charged supramolecular chiral media; the chiral separation conditions of racemic amino acid derivatives were optimized, and the resolution of racemic dansyl amino acids were obtained as well. The experiment is based on the construction of new engineering chemistry specialty, covering the basic chemical knowledge of green synthesis, accurate instrument analysis, physical and chemical separation mechanism, and inorganic material chemistry, as well as integrating the advanced technical theories and industrial applications, thereby creating a new paradigm for the cultivation of chemistry talents under the guidance of ideological and political education.
- Cationic cyclodextrin,
- Green click chemistry,
- Course ideology and politics,
- Chemistry experiment
1. [1]
  Dou, X.; Mehwish, N.; Zhao, C. Acc. Chem. Res. 2020, 53, 852.
2. [2]
  Sun, Z.; Hou, J.; Li, L.; Tang, Z. Coord. Chem. Rev. 2020, 425, 213481.
3. [3]
  Gogoi, A.; Nongrum, S.; Bez, G. Curr. Org. Chem. 2021, 25, 1566.
4. [4]
  Li, L.; Zhang, J.; Dai, H. Anal. Chem. 2021, 93, 14425.
5. [5]
  Liu, Z.; Ye, L.; Xi, J.; Wang, J.; Feng, Z.-G. Prog. Polym. Sci. 2021, 118, 101408.
6. [6]
  Lu, X. L.; Chen, M.; Yang, J. T. J. Chromatogr. A 2022, 1664, 462786.
7. [7]
  Shaw, S.; White, J. D. Chem. Rev. 2019, 119, 9381.
8. [8]
  Topuz, F.; Holtzl, T.; Szekely, G. Chem. Eng. J. 2021, 419, 129443.
9. [9]
  Dalgliesh, C. J. Chem. Soc. 1952, 3940.
10. [10]
  Siles, B. A.; Halsall, H. B.; Dorsey, J. G. J. Chromatogr. A 1995, 704, 289.
1. [1]
  Liwei Wang , Guangran Ma , Li Wang , Fugang Xu . A Comprehensive Analytical Chemistry Experiment: Colorimetric Detection of Vitamin C Using Nanozyme and Smartphone. University Chemistry, 2024, 39(8): 255-262. doi: 10.3866/PKU.DXHX202312094
2. [2]
  Yongmei Liu , Shuyong Zhang , Shuangyan Huan , Genrong Qiang , Xia Zhang , Huan Jiao , Jiangang Li , Zhanxiang Liu , Qizhi Yao , Hongxia Fan . Recommendations for Integrating Ideological and Political Education into Chemistry Laboratory Courses for Chemistry Majors at Higher Education Institutions. University Chemistry, 2025, 40(5): 189-205. doi: 10.12461/PKU.DXHX202412145
3. [3]
  Shuyong Zhang , Wenfeng Jiang , Changsheng Lu , Genrong Qiang , Yongmei Liu , Xiangyang Tang , Dongcheng Liu , Lili Zhang . Suggestions on Construction and Evaluation Standards for First-Class Chemical Experiment Teaching. University Chemistry, 2025, 40(5): 9-14. doi: 10.12461/PKU.DXHX202502114
4. [4]
  Hua Hou , Baoshan Wang . Course Ideology and Politics Education in Theoretical and Computational Chemistry. University Chemistry, 2024, 39(2): 307-313. doi: 10.3866/PKU.DXHX202309045
5. [5]
  Sijiang Hu , Hongqiang Wang , Jiming Peng , Fenghua Zheng , Qichang Pan , Kui Liu , Qingyu Li . Ideological and Political Education Practice of the Comprehensive Applied Chemistry Laboratory for Emerging Engineering Education. University Chemistry, 2024, 39(2): 214-220. doi: 10.3866/PKU.DXHX202307019
6. [6]
  Hongxia Fan , Xia Zhang , Qizhi Yao , Yongmei Liu , Chengwen Chai , Wenxia Yuan , Chen Wang , Shuyong Zhang . Suggestion for the Construction of Ideological and Political Education in Comprehensive/Design Chemical Experiment Courses in Higher Education. University Chemistry, 2025, 40(5): 206-214. doi: 10.12461/PKU.DXHX202503068
7. [7]
  Fuping Tian , Yue Dai , Feifei Huang , Yu Wang , Xinkui Wang , Xuzhen Wang , Wenfeng Jian . 物理化学实验课程思政的建设与实践. University Chemistry, 2025, 40(6): 22-27. doi: 10.12461/PKU.DXHX202408074
8. [8]
  Zhuoxi Li , Jieshu Wei , Yanqin Cheng . Practice of Integrating Ideological and Political Education into Inorganic Chemistry Curriculum. University Chemistry, 2024, 39(2): 255-262. doi: 10.3866/PKU.DXHX202308084
9. [9]
  Zhichang Xiao , Xiaohui Li , Ling Zhang , Huimin Liu . Exploration of Ideological and Political Construction in University Foundation Course of Organic Chemistry. University Chemistry, 2024, 39(2): 314-320. doi: 10.3866/PKU.DXHX202308058
10. [10]
  Tian Li , Liping Zhang , Ling Liu , Ruifang Li , Longfei Mao , Hui Yang . Reform and Practice of Analytical Chemistry Teaching under the Guidance of Course Ideology and Politics. University Chemistry, 2024, 39(6): 189-194. doi: 10.3866/PKU.DXHX202310014
11. [11]
  Sifang Zhang , Yanli Tan , Yu Tao , Jiaoyan Zhao , Haihong Zhu . Exploration and Practice of Ideological and Political Cases in the Course of Chemistry History and Methodology. University Chemistry, 2024, 39(10): 377-388. doi: 10.12461/PKU.DXHX202312067
12. [12]
  Chao Zheng , Xuxu Zheng . Problems and Countermeasures of Ideological and Political Practice in Public Basic Course University Chemistry. University Chemistry, 2025, 40(4): 195-199. doi: 10.12461/PKU.DXHX202405194
13. [13]
  Huan Jiao , Ying Zhang , Yi Yan , Shuxian Bi , Yongmei Liu , Lingling Wei , Quanguo Zhai , Shuyong Zhang . Suggestion on Enhancing of Ideological and Political Design and Integration in Undergraduate Project for Chemistry Majors. University Chemistry, 2025, 40(5): 215-223. doi: 10.12461/PKU.DXHX202411001
14. [14]
  Dongxue Han , Huiliang Sun , Li Niu . Virtual Reality Technology for Safe and Green University Chemistry Experimental Education. University Chemistry, 2024, 39(8): 191-196. doi: 10.3866/PKU.DXHX202312055
15. [15]
  Biaolin Yin , Yuanfu Deng , Dongen Lin . Exploration and Practice of Integrating Ideological and Political Education and Innovative Thinking into “Organic Chemistry” Teaching. University Chemistry, 2024, 39(2): 286-291. doi: 10.3866/PKU.DXHX202308026
16. [16]
  Xinghai Liu , Hongke Wu . Exploration and Practice of Ideological and Political Education in Heterocyclic Chemistry Based on "Fentanyl" Event. University Chemistry, 2024, 39(8): 359-364. doi: 10.3866/PKU.DXHX202312100
17. [17]
  Xiangli Wang , Yuanfu Deng . Teaching Design of Elemental Chemistry from the Perspective of “Curriculum Ideology and Politics”: Taking Arsenic as an Example. University Chemistry, 2024, 39(2): 270-279. doi: 10.3866/PKU.DXHX202308092
18. [18]
  Hongmei Zhao , Ziqiang Lu , Song Li , Xingyu Li , Chengting Zi , Xingli Fan , Xiangdong Qin . Exploration and Practice of Physical Chemistry Teaching under the Guidance of Course Ideological and Political Education. University Chemistry, 2024, 39(3): 210-217. doi: 10.3866/PKU.DXHX202309006
19. [19]
  Hongyun Liu , Jiarun Li , Xinyi Li , Zhe Liu , Jiaxuan Li , Cong Xiao . Course Ideological and Political Design of a Comprehensive Chemistry Experiment: Constructing a Visual Molecular Logic System Based on Intelligent Hydrogel Film Electrodes. University Chemistry, 2024, 39(2): 227-233. doi: 10.3866/PKU.DXHX202309070
20. [20]
  Changyan Sun , Hualei Zhou , Bin Dong . Application of “PBL” Teaching Mode in Inorganic Chemistry Experimental Education in the Perspective of Course Ideology and Politics: Taking Preparation of Manganese Carbonate as an Example. University Chemistry, 2024, 39(11): 378-383. doi: 10.12461/PKU.DXHX202402016

Get Citation

PDF

XML

Metrics

PDF Downloads(5)
Abstract views(1177)
HTML views(111)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142