Citation: Rongbin Peng, Shang Zhou, Ziyang Wang, Dongen Lin, Chuanle Zhu. Comprehensive Experimental Design of Three Component Reaction for the Synthesis of 5-(4-Methylphenyl)-3-Trifluoromethyl-1H-Pyrazole[J]. University Chemistry, ;2023, 38(8): 248-258. doi: 10.3866/PKU.DXHX202209026 shu

Comprehensive Experimental Design of Three Component Reaction for the Synthesis of 5-(4-Methylphenyl)-3-Trifluoromethyl-1H-Pyrazole

School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China

Corresponding author: Chuanle Zhu, cechlzhu@scut.edu.cn
Received Date: 11 September 2022

Through scientific research back-feeding teaching, the two concepts of "multicomponent reaction" and "fluorinated organic compound" were integrated into undergraduate experiment teaching, and 5-(4-methylphenyl)-3-trifluoromethyl-1H-pyrazole was synthesized by the three-component reaction. This reaction features mild experimental conditions, simple operations, high yield, good reproducibility, and high safety. This comprehensive experiment integrates science and education and combines theory with practice, thus helping students to understand the new concept of step-economic synthesis and to establish the concept of green chemistry. This is a new subject suitable to introduce into the current organic experiment teaching course.
- Organic fluorine chemistry,
- Multi-component reaction,
- 3-Trifluoromethyl-1H-pyrazole,
- Fluorinated building block
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