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Citation: Jun Liu, Shidong Zhou. Replacing Benzene with Aniline for Synthesis of Acetophenone: A Synthetic Chemistry Experiment[J]. University Chemistry, ;2022, 37(12): 211205. doi: 10.3866/PKU.DXHX202112050 shu

Replacing Benzene with Aniline for Synthesis of Acetophenone: A Synthetic Chemistry Experiment

Jun Liu ,
Shidong Zhou ^,

Department of Chemistry, Northeast Normal University, Changchun 130024, China

Corresponding author: Shidong Zhou, zhousd736@nenu.edu.cn
Received Date: 20 December 2021

An experiment was designed to replace benzene with aniline as the raw material in the preparation of p-aminoacetophenone by Friedel-Crafts acylation. In addition to the safety benefits, this modification challenges the students’ ability to continuously synthesize the target product in multiple steps; encourages the students to think about the application of amino protection during synthesis; promotes the use of scientific methods and thinking.
- Friedel-Crafts acylation,
- Aniline,
- Acetophenone
1. [1]
2. [2]
3. [3]
4. [4]
5. [5]
6. [6]
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