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Citation: Shui Hu, Rong Lai, Houjin Li, Kejia Zhu, Lei Zhou, Guang Shao. 非那西丁的合成与复方阿司匹林的主成分分析——推荐一个有机化学实验[J]. University Chemistry, ;2021, 36(12): 210301. doi: 10.3866/PKU.DXHX202103014 shu

非那西丁的合成与复方阿司匹林的主成分分析——推荐一个有机化学实验

Shui Hu ¹ ,
Rong Lai ¹ ,
Houjin Li ¹ ,
Kejia Zhu ¹ ,
Lei Zhou ¹ ,
Guang Shao ^1,2,,

1.
School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China;
2.
School of Chemistry Engineering and Technology, Sun Yat-Sen University, Zhuhai 519082, Guangdong Province, China

Corresponding author: Guang Shao, shaog@mail.sysu.edu.cn
Received Date: 8 March 2021

以对氨基苯乙醚为原料，与乙酸成盐提高溶解度与反应活性，再与乙酸酐发生亲核取代反应，两步制备非那西丁。以核磁共振氢谱对化合物结构进行解析，并且利用薄层色谱和高效液相色谱对复方阿司匹林中的有效成分进行分析，讨论了色谱技术之间的区别与联系。本实验内容包括加热回流、离心、重结晶、核磁共振波谱以及薄层色谱和高效液相色谱的应用，有利于培养学生的综合分析问题能力。
- Phenacetin,
- Compound aspirin,
- Thin layer chromatography,
- High performance liquid chromatography
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