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Citation: ZHANG Weiguang, ZHANG Shilin, GUO Dong, ZHAO Lei, YU Lajia, ZHANG Hui, HE Yujian. Great Concern for Chiral Pharmaceuticals from the Thalidomide Tragedy[J]. University Chemistry, ;2019, 34(9): 1-12. doi: 10.3866/PKU.DXHX201904021 shu

Great Concern for Chiral Pharmaceuticals from the Thalidomide Tragedy

ZHANG Weiguang ^1, ,
ZHANG Shilin ² ,
GUO Dong ² ,
ZHAO Lei ² ,
YU Lajia ² ,
ZHANG Hui ² ,
HE Yujian ³

1.
School of Chemistry and Environment, South China Normal University, Guangzhou 510006, P. R. China;
2.
College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian Province, P. R. China;
3.
School of Chemical Science, University of Chinese Academy of Sciences, Beijing 100039, P. R. China

Received Date: 11 April 2019

Since the Thalidomide tragedy in the 1960s, the issue of chirality has become increasingly important in the fields of novel drug development and pharmaceutical research. Enantiomers may exhibit different pharmacologic, pharmacokinetic, metabolic, and toxicological activity in living organisms. Recently, chiral High-Performance Liquid Chromatography (HPLC) technology combined with chiroptical spectroscopy has been widely used in separation and analysis of chiral compounds, and will play a critical role in the detection and quality control of chiral pharmaceuticals.
- Chiral drug,
- Thalidomide tragedy,
- Chiral health-care product,
- Enantiomer,
- Enantioselectivity
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