Citation: LIAO Zerong, LI Yongrui, GU Le, LEI Runhong, MIAO Yunfei, LAN Hongying, DENG Yulin, GENG Lina. Advances in microfluidic chip-based extracellular vesicle separation[J]. Chinese Journal of Chromatography, ;2019, 37(4): 343-347. doi: 10.3724/SP.J.1123.2018.11045 shu

Advances in microfluidic chip-based extracellular vesicle separation

LIAO Zerong ^1, ,
LI Yongrui ¹ ,
GU Le ² ,
LEI Runhong ³ ,
MIAO Yunfei ¹ ,
LAN Hongying ¹ ,
DENG Yulin ¹ ,
GENG Lina ¹

1.
Beijing Institute of Technology, Beijing 100081, China;
2.
BOE Sensor Technology Group Co., Ltd, Beijing 100176, China;
3.
Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China

Received Date: 30 November 2018

Fund Project: Specially-Funded Program on National Key Scientific Instruments and Equipment Development (No. 2012YQ04014006).

Extracellular vesicles (EVs) are hemispherical vesicles that have a lipid bilayer. Studies have shown that EVs have important biological functions. The amount, types, and compositional changes of proteins, lipids and ribonucleic acids are closely related to diseases. The separation and capture of EVs from the complicated body fluid samples is a prerequisite for medical research and liquid biopsy based on EVs. However, presently the majority of EVs separation and capture still use the traditional separation methods with low purity and low efficiency. Therefore, efficient and highly selective EVs separation method is in urgent need. To meet this challenge, advanced microfluidic chip technology, which has the advantages of miniaturization, integration, and automation, can be utilized. The development of EV separation technology combined with microfluidic chips has become the focus of research. This paper summarizes the latest research progress in this area.
- microfluidic chip,
- extracellular vesicles,
- separation
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