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Citation: YANG Wenquan, ZHANG Xiaoyan, YAO Qian, ZHOU Yangjuan, HU Yawen, WANG Maohua, TANG Maozhi. Determination of 50 antibiotic residues in drone pupa powder by liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chromatography, ;2019, 37(1): 46-53. doi: 10.3724/SP.J.1123.2018.08046 shu

Determination of 50 antibiotic residues in drone pupa powder by liquid chromatography-tandem mass spectrometry

1.
Animal, Plant and Food Inspection Center, Nanjing Customs, Nanjing 210001, China;
2.
Southeast University Chengxian College, Nanjing 210088, China;
3.
China Certification & Accreditation Institute, Beijing 100020, China

Received Date: 10 September 2018

Fund Project: National Key Research and Development Program (No. 2018YFF0215605).

A method was established for the determination of 50 kinds of antibiotic residues (macrolides, quinolones, sulfonamides, tetracyclines, nitroimidazoles, lincomycin and chloramphenicol) in drone pupa powder by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The samples were extracted with perchloric acid and lead acetate solution, and the protein was precipitated. The extraction solution was adjusted to pH 8 using dipotassium hydrogen phosphate, then the solution was purified by solid phase extraction (SPE) and analyzed by LC-MS/MS. The target compounds in the drone pupa powder were determined quantitatively and quantitatively by using multiple reaction monitoring and positive ion or negative ion modes. The recoveries of the 50 antibiotics were in the range of 70.2%-118.3%, and the relative standard deviations (RSDs) were 1.8%-13.6%. The method is simple, selective, and can be suitable for the analysis and confirmation of veterinary drug residues in drone pupa powder.
- liquid chromatography-tandem mass spectrometry (LC-MS/MS),
- solid phase extraction (SPE),
- antibiotic residues,
- drone pupa powder
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