Citation: WANG Jianling, XIAO Xiaofeng, CHEN Tong, LIU Tingfei, HE Jun, DENG Hongyi, YANG Juanjuan. Simultaneous determination of total specific migration limit of seven benzene polycarbonic acids and their derivatives in food simulants by high performance liquid chromatography-ultraviolet detection[J]. Chinese Journal of Chromatography, ;2015, 33(8): 856-863. doi: 10.3724/SP.J.1123.2015.04011 shu

Simultaneous determination of total specific migration limit of seven benzene polycarbonic acids and their derivatives in food simulants by high performance liquid chromatography-ultraviolet detection

1.
Taizhou Entry-Exit Inspection and Quarantine Bureau, Taizhou 318000, China

Corresponding author: XIAO Xiaofeng,
Received Date: 8 April 2015

Fund Project: 国家质检总局科技计划项目(2013IK022). (2013IK022)

A novel method for simultaneous determination of total specific migration limits (SML(T)) of trimellitic, isophthalic, terephthalic, phthalic acid and their derivatives (1,2,4-benzenetricarboxylic anhydride, isophthaloyl chloride and terephthaloyl chloride) in food simulants (10% (v/v) ethanol, 20% (v/v) ethanol, 50% (v/v) ethanol, 3% (w/v) acetic acid and olive oil) was developed by high performance liquid chromatography-ultraviolet detection (HPLC-UV). After the migration test, the soaking solution was cooled down and vortexed. After the extraction of olive oil food simulants with 0.1% (w/v) ammonium acetate aqueous solution, the clear aqueous solution or other aqueous food simulants was filtered through a hydrophilic polytetrafluoroethylene filter with a disposable syringe before injection. The Synergi Polar-RP column (250 mm×4.6 mm, 4 μm) and gradient elution mode were selected. The variable wavelength detector was set at 232 nm. The limits of quantification were 0.1-0.2 mg/kg; the linearity of the method was good with r²>0.99991 over the range from 0.5 to 12 mg/L for aqueous food simulants or 0.5 to 12 mg/kg for olive oil food simulants. The recoveries of them were between 94.3% and 105% with the relative standard deviations between 0.1% and 2.3% at the levels of 1.25, 2.50, 6.25 mg/kg. The method shows the low limits of detection, good recoveries and accuracies, and meets the requirement of (EU)No 10/2011 regulation for the total specific migration limits of trimellitic, isophthalic, terephthalic, phthalic acids and their derivatives. The method has been applied to the analysis of food contact material samples.
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沈阳化工大学材料科学与工程学院沈阳 110142