Citation: ZHU Pingping, YUE Zhenfeng, ZHENG Zongkun, ZHANG Yi, LI Wenyin, ZHAO Fengjuan, XIAO Chengui, BAI Runye, LIN Wei. Determination of perfluoroalkyl acids in lamb liver by high performance liquid chromatography-tandem mass spectrometry combined with dispersive solid phase extraction[J]. Chinese Journal of Chromatography, ;2015, 33(5): 494-500. doi: 10.3724/SP.J.1123.2014.12034 shu

Determination of perfluoroalkyl acids in lamb liver by high performance liquid chromatography-tandem mass spectrometry combined with dispersive solid phase extraction

ZHU Pingping ^1,2 ,
YUE Zhenfeng ^1,, ,
ZHENG Zongkun ² ,
ZHANG Yi ¹ ,
LI Wenyin ^1,2 ,
ZHAO Fengjuan ¹ ,
XIAO Chengui ¹ ,
BAI Runye ^1,2 ,
LIN Wei ^1,2

1.
1. Food Inspection and Quarantine Center, Shenzhen Entry-Exit Inspection and Quarantine Bureau; Shenzhen Key Laboratory of Detection Technology R. & D. on Food Safety, Shenzhen 518045, China;

Corresponding author: YUE Zhenfeng,
Received Date: 25 December 2014
Available Online: 18 March 2015
Fund Project: 国家科技基础性工作专项重点项目(2013FY113100) (2013FY113100)科技部"十二五"科技支撑计划项目(2012BAD33B02). (2012BAD33B02)

A method was developed for the determination of 19 perfluoroalkyl acids (PFAs) in lamb liver by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) combined with dispersive solid phase extraction. The sample was extracted with acidified acetonitrile, and then cleaned-up by a mixture of N-propylethylenediamine (PSA), C18 and graphitized carbon black (GCB) sorbents. The 19 PFAs were analyzed by HPLC-MS/MS with a C18 chromatographic column, adopting the multiple reaction monitoring (MRM) mode with negative electrospray ionization. The effects of the dosages of hydrochloric acid and the sorbents on the recoveries of the 19 PFAs were studied. For accurate quantitative analysis, the isotope internal standard method was used. The calibration curves were linear with the correlation coefficients over 0.998 in the range of 0.05-20 μg/kg for the 19 PFAs. The limits of detection were 0.004-0.111 μg/kg. The limits of quantification were 0.012-0.370 μg/kg. The mean recoveries of the 19 PFAs at spiked levels of 0.5, 1.0, 2.0 μg/kg were in the range from 80% to 128% with the relative standard deviations of 0.31%-11.1%. The developed method is rapid, simple, accurate. It is suitable for the determination of the 19 PFAs in large quantities of lamb liver samples.
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