Citation: LIU Junyan, CAO Zhe, LI Jiwen, WANG Zheming, WANG Chuan, GU Songyuan. Application of gas chromatography-high resolution quadrupole time of flight mass spectrometry to the analysis of benzaldehyde, benzyl alcohol, acetophenone and phenylacetaldehyde in complex aromatic samples[J]. Chinese Journal of Chromatography, ;2015, 33(2): 146-151. doi: 10.3724/SP.J.1123.2014.09051 shu

Application of gas chromatography-high resolution quadrupole time of flight mass spectrometry to the analysis of benzaldehyde, benzyl alcohol, acetophenone and phenylacetaldehyde in complex aromatic samples

LIU Junyan ^1,, ,
CAO Zhe ² ,
LI Jiwen ¹ ,
WANG Zheming ¹ ,
WANG Chuan ¹ ,
GU Songyuan ¹

1.
1. Sinopec Shanghai Research Institute of Petrochemical Technology, Shanghai 201208, China;

Corresponding author: LIU Junyan,
Received Date: 8 October 2014
Available Online: 30 October 2014

The study focuses on the quantitative analytical characterization of benzaldehyde, benzyl alcohol, acetophenone and phenylacetaldehyde in complex aromatic samples by gas chromatography-high resolution quadrupole time of flight mass spectrometry (GC-QTOF MS). The four compounds in real sample were accurately qualified and quantified through a comprehensive analysis of the GC retention times and the accurate masses of the ion fragments obtained by the high resolution MS. The new method therefore effectively avoids the interference of the real sample substrate, which reduces the accuracy of the analysis results. The peak area of the characteristic ion fragment for each compound was used for quantitation calculation. The MS signal responses of the four compounds showed good linear relationships with the corresponding mass concentrations and the linear regression coefficients were greater than 0.99. The method recoveries were 87.97%-103.01%. The limits of detection (LODs) were 0.01, 0.03, 0.02 and 0.01 mg/L for benzaldehyde, benzyl alcohol, acetophenone and phenylacetaldehyde respectively. The contents of the four compounds in three real samples were analyzed. The study provided a new strategy for oxygenate analysis in complex aromatic samples using GC-QTOF MS. By measuring the accurate masses, the new method reduces the reliance on chromatographic separation ability and makes up the shortcomings of the traditional GC-MS methods.
- gas chromatography (GC),
- high resolution time of flight mass spectrometry (HR TOF MS),
- oxygenates,
- complex aromatic samples
1. [1]
  [1] Holmes J C, Morrell F A. Appl Spectrosc, 1957, 11(2): 86
2. [2]
  [2] Zheng M H, Wu J J. Chinese Journal of Chromatography (郑明辉, 吴嘉嘉. 色谱), 2011, 29(4): 281
3. [3]
  [3] Lü Q, Zhang Q, Bai H, et al. Chinese Journal of Chromatography (吕庆, 张庆, 白桦, 等. 色谱), 2012, 30(5): 480
4. [4]
  [4] Lü Q, Zhang Q, Bai H, et al. Chinese Journal of Analysis Laboratory (吕庆, 张庆, 白桦, 等. 分析试验室), 2012, 31(4): 45
5. [5]
  [5] Ma Z L, Zhao W, Li L Y, et al. Chinese Journal of Chromatography (马智玲, 赵文, 李凌云, 等. 色谱), 2013, 31(3): 228
6. [6]
  [6] Zhang L, Shang C X, Sun C. Chinese Journal of Chromatography (张莉, 尚楚翔, 孙成. 色谱), 2014, 32(6): 653
7. [7]
  [7] Jia W, Chu X G, Ling Y, et al. J Chromatogr A, 2014, 1362: 110
8. [8]
  [8] Jia W, Ling Y, Lin Y H, et al. J Chromatogr A, 2014, 1336: 67
9. [9]
  [9] Casado J, Rodriguez I, Carpinteiro I, et al. J Chromatogr A, 2013, 1293: 126
10. [10]
  [10] Zushi Y, Hashimoto S, Tamada M, et al. J Chromatogr A, 2014, 1338: 117
11. [11]
  [11] Zhu X Y, Liu Z L, Xu Y Q, et al. Acta Petrolei Sinica (祝馨怡, 刘泽龙, 徐延勤, 等. 石油学报), 2011, 27(5): 797
12. [12]
  [12] Lu X B, Chen J P, Wang S Q, et al. Chinese Journal of Chromatography (卢宪波, 陈吉平, 王淑秋, 等. 色谱), 2012, 30(9): 915
13. [13]
  [13] Yoshida M, Hatano N, Nishiumi S, et al. J Gastroenterol, 2012, 47: 9
14. [14]
  [14] Portoles T, Mol J G J, Sancho J V, et al. J Chromatogr A, 2014, 1339: 145
15. [15]
  [15] Fan R J, Zhang F, Guo Y L. Journal of Instrumental Analysis (范若静, 张芳, 郭寅龙. 分析测试学报), 2012, 31(9): 1051
16. [16]
  [16] Wang W W, Yu C T. Environmental Chemistry (王雯雯, 余翀天. 环境化学), 2012, 31(10): 1660
17. [17]
  [17] Peng Z L, Wang C, Zhang Y H. Chinese Journal of Analysis Laboratory (彭振磊, 王川, 张育红. 分析试验室), 2010, 29(8): 86
18. [18]
  [18] GB 3915-1998
19. [19]
  [19] GB/T 12688.5-90
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