Citation: ZHANG Yong, MEI Meng, HUANG Xiaojia, YUAN Dongxing. Determination of nitrofuran residues in feed and water samples by monolith-based stir bar sorptive extraction and high performance liquid chromatography[J]. Chinese Journal of Chromatography, ;2014, 32(4): 402-406. doi: 10.3724/SP.J.1123.2013.10013 shu

Determination of nitrofuran residues in feed and water samples by monolith-based stir bar sorptive extraction and high performance liquid chromatography

1.
Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystem, College of the Environment and Ecology, Xiamen University, Xiamen 361005, China

Corresponding author: HUANG Xiaojia,
Received Date: 16 October 2013
Available Online: 17 December 2013
Fund Project: 国家自然科学基金项目(21377105，21077085)；福建省新世纪优秀人才项目. (21377105，21077085)

A simple, efficient and sensitive method for the simultaneous determination of nitrofurantoin (NFT), furazolidone (FZD) and nitrofurazone (NFZ) in feed and water samples was developed by stir bar sorptive extraction (SBSE) coupled to high performance liquid chromatography with diode array detection. The SBSE based on poly (vinylimidazole-divinylbenzene) (VIDB) monolithic material as coating was used to concentrate the three target analytes. To obtain the optimum extraction performance, several VIDB-SBSE parameters were investigated and studied, including pH value, ionic strength of sample matrix, extraction and desorption time. Under the optimized experimental conditions, the linear ranges were 0.5-200 μg/L for FZD, 0.25-200 μg/L for NFT and NFZ. The limits of detection (S/N=3) were in the range of 0.068-0.11 μg/L for the three analytes. The precision of the proposed method was evaluated in terms of intra- and inter-day repeatability calculated as RSD, and it was found that the RSDs were all below 6%. The developed method was successfully applied to the determination of nitrofuran residues in animal feed and water samples. The satisfactory recoveries of the spiked target compounds were in the range of 80.6%-108%.
- stir bar sorptive extraction (SBSE),
- monolithic material,
- high performance liquid chromatography (HPLC),
- nitrofuran residues,
- feed,
- water samples
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沈阳化工大学材料科学与工程学院沈阳 110142