Citation: CHEN Yu, WANG Jie, LIU Zhong-Ming. Graphene and Its Derivatives-Based Biosensing System[J]. Chinese Journal of Analytical Chemistry, ;2012, 40(11): 1772-1779. doi: 10.3724/SP.J.1096.2012.20436 shu

Graphene and Its Derivatives-Based Biosensing System

CHEN Yu ¹ ,
WANG Jie ^1,2,, ,
LIU Zhong-Ming ¹

1.
¹ Department of Medical Research, General Hospital of Guangzhou Military Command, Guangzhou 510010, China;

Corresponding author: WANG Jie,
Received Date: 23 April 2012
Available Online: 7 July 2012
Fund Project: 本文系广东省部学学研项目(No. 2010B090400187) (No. 2010B090400187)传感技术联合国家重点实验室基金课题(No. Skt003)资助 (No. Skt003)

Graphene and its derivatives have recently attracted considerable attention because of their vast array of distinct electronic, thermal, mechanical, optical, and electrochemical properties. Thus, this set of compounds has become a research hotspot and a promising area for scientific research. The significantly high carrier mobility, high electrical conductivity, high surface area, ease of functionalization, strong fluorescence quenching, and affinity for biomolecules make graphene and its derivatives suitable in the development of biosensing systems. In our review, we describe the recent applications of graphene and its derivatives to field-effect transistors as well as to electrochemical, piezoelectric, photoluminescence, and electrochemiluminescence biosensing systems.
- Graphene,
- Graphene oxide,
- Electrochemical,
- Electrochemiluminescence,
- Biosensing system,
- Review
1. [1]
  1 Novoselov K S, Geim A K, Morozov S V, Jiang D, Zhang Y, Dubonos S V, Grigorieva I V, Firsov A A. Science, 2004, 306(5696): 666-669
2. [2]
  2 Geim A K. Science, 2009, 324(5934): 1530-1534
3. [3]
  3 Zhu Y, Murali S, Cai W, Li X, Suk J W, Potts J R, Ruoff R S. Adv. Mater., 2010, 22(35): 3906-3924
4. [4]
  4 Su B, Tang D, Li Q, Tang J, Chen G. Anal. Chim. Acta, 2011, 692(1-2): 116-124
5. [5]
  5 Lu L M, Li H B, Qu F, Zhang X B, Shen G L, Yu R Q. Biosens. Bioelectron., 2011, 26(8): 3500-3504
6. [6]
  6 Liu Q, Shi J, Cheng M, Li G, Cao D, Jiang G. Chem. Commun., 2012, 48(13): 1874-1876
7. [7]
  7 Liu F, Choi J Y, Seo T S. Biosens. Bioelectron., 2010, 25(10): 2361-2365
8. [8]
  8 Stankovich S, Dikin D A, Dommett G H B, Kohlhaas K M, Zimney E J, Stach E A, Piner R D, Nguyen S T, Ruoff R S. Chem. Commun., 2006, 442(7100): 282-286
9. [9]
  9 Novoselov K S, Jiang Z, Zhang Y, Morozov S V, Stormer H L, Zeitler U, Maan J C, Boebinger G S, Kim P, Geim A K. Science, 2007, 315(5817): 1379
10. [10]
  10 Novoselov K S, Geim A K, Morozov S V, Jiang D, Katsnelson M I, Grigorieva I V, Dubonos S V, Firsov A A. Chem. Commun., 2005, 438(7065): 197-200
11. [11]
  11 Jung J H, Cheon D S, Liu F, Lee K B, Seo T S. Angew. Chem. Int. Edit., 2010, 49(33): 5708-5711
12. [12]
  12 Loh K P, Bao Q, Eda G, Chhowalla M. Nat. Chem., 2010, 2(12): 1015-1024
13. [13]
  13 Robinson J T, Perkins F K, Snow E S, Wei Z, Sheehan P E. Nano Lett., 2008, 8(10): 3137-3140
14. [14]
  14 Shi Y, Huang W T, Luo H Q, Li N B. Chem. Commun., 2011, 47(16): 4676-4678
15. [15]
  15 Ohno Y, Maehashi K, Matsumoto K. Biosens. Bioelectron., 2010, 26(4): 1727-1730
16. [16]
  16 Pumera M. Mater. Today, 2011, 14(7-8): 308-315
17. [17]
  17 Nagashio K, Nishimura T, Kita K, Toriumi A. Appl. Phys. Express, 2009, 2(2): 025003
18. [18]
  18 Shao Y, Wang J, Wu H, Liu J, Aksay I A, Lin Y. Electroanalysis, 2010, 22(10): 1027-1036
19. [19]
  19 Geim A K, Novoselov K S. Nat. Mater, 2007, 6(3): 183-191
20. [20]
  20 Ohno Y, Maehashi K, Matsumoto K. J. Am. Chem. Soc., 2010, 132(51): 18012-18013
21. [21]
  21 Mohanty N, Berry V. Nano Lett., 2008, 8(12): 4469-4476
22. [22]
  22 Dong X, Huang W, Chen P. Nanoscale Res. Lett., 2011, 6(1): 60
23. [23]
  23 Dong X, Shi Y, Huang W, Chen P, Li L J. Adv. Mater., 2010, 22(14): 1649-1653
24. [24]
  24 Mao S, Lu G, Yu K, Bo Z, Chen J. Adv. Mater., 2010, 22(32): 3521-3526
25. [25]
  25 Lu G, Ocola L E, Chen J. Appl. Phys. Lett., 2009, 94(8): 083111-083113
26. [26]
  26 Lu G, Ocola L E, Chen J. Nanotechnology, 2009, 20(44): 445502
27. [27]
  27 Reina A, Jia X, Ho J, Nezich D, Son H, Bulovic V, Dresselhaus M S, Kong J. Nano Lett., 2008, 9(1): 30-35
28. [28]
  28 Li X, Cai W, An J, Kim S, Nah J, Yang D, Piner R, Velamakanni A, Jung I, Tutuc E, Banerjee S K, Colombo L, Ruoff R S. Science, 2009, 324(5932): 1312-1314
29. [29]
  29 Reina A, Thiele S, Jia X, Bhaviripudi S, Dresselhaus M, Schaefer J, Kong J. Nano Res., 2009, 2(6): 509-516
30. [30]
  30 Kim K S, Zhao Y, Jang H, Lee S Y, Kim J M, Kim K S, Ahn J H, Kim P, Choi J Y, Hong B H. Chem. Commun., 2009, 457(7230): 706-710
31. [31]
  31 Reina A, Son H, Jiao L, Fan B, Dresselhaus M S, Liu Z, Kong J. J. Phys. Chem. C, 2008, 112(46): 17741-17744
32. [32]
  32 Kim S N, Rusling J F, Papadimitrakopoulos F. Adv. Mater., 2007, 19(20): 3214-3228
33. [33]
  33 Huang J, Liu Y, You T. Anal. Methods, 2010, 2(3): 202-211
34. [34]
  34 Huang Y, Dong X, Shi Y, Li C M, Li L J, Chen P. Nanoscale, 2010, 2(8): 1485-1488
35. [35]
  35 Sun Y, Buck H, Mallouk T E. Anal. Chem., 2001, 73(7): 1599-1604
36. [36]
  36 Shi W, Ma Z. Biosens. Bioelectron., 2010, 26(3): 1098-1103
37. [37]
  37 Haun J B, Yoon T J, Lee H, Weissleder R. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2010, 2(3): 291-304
38. [38]
  38 Yun Y, Dong Z, Shanov V, Heineman W R, Halsall H B, Bhattacharya A, Conforti L, Narayan R K, Ball W S, Schulz M J. Nano Today, 2007, 2(6): 30-37
39. [39]
  39 Pumera M. The Chem. Rec., 2009, 9(4): 211-223
40. [40]
  40 Pumera M. Chem. Soc. Rev., 2010, 39(11): 4146-4157
41. [41]
  41 Pumera M, Ambrosi A, Bonanni A, Chng E L K, Poh H L. TrAC Trends in Anal. Chem., 2010, 29(9): 954-965
42. [42]
  42 Allen M J, Tung V C, Kaner R B. Chem. Rev., 2009, 110(1): 132-145
43. [43]
  43 Brownson D A C, Banks C E. Analyst, 2010, 135(11): 2768-2778
44. [44]
  44 Lin W J, Liao C S, Jhang J H, Tsai Y C. Electrochem. Commun., 2009, 11(11): 2153-2156
45. [45]
  45 Tang L, Wang Y, Li Y, Feng H, Lu J, Li J. Adv. Funct. Mater., 2009, 19(17): 2782-2789
46. [46]
  46 Garaj S, Hubbard W, Reina A, Kong J, Branton D, Golovchenko J A. Chem. Commun., 2010, 467(7312): 190-193
47. [47]
  47 Shang N G, Papakonstantinou P, McMullan M, Chu M, Stamboulis A, Potenza A, Dhesi S S, Marchetto H. Adv. Funct. Mater., 2008, 18(21): 3506-3514
48. [48]
  48 Lim C X, Hoh H Y, Ang P K, Loh K P. Anal. Chem., 2010, 82(17): 7387-7393
49. [49]
  49 Zhou M, Zhai Y, Dong S. Anal. Chem., 2009, 81(14): 5603-5613
50. [50]
  50 Andreescu S, Luck L A. Anal. Biochem., 2008, 375(2): 282-290
51. [51]
  51 Xiao Y, Patolsky F, Katz E, Hainfeld J F, Willner I. Science, 2003, 299(5614): 1877-1881
52. [52]
  52 Su B, Tang J, Yang H, Chen G, Huang J, Tang D. Electroanalysis, 2011, 23(4): 832-841
53. [53]
  53 Zhu C, Guo S, Zhai Y, Dong S. Langmuir, 2010, 26(10): 7614-7618
54. [54]
  54 Dey R S, Raj C R. J. Phys. Chem. C, 2010, 114(49): 21427-21433
55. [55]
  55 Hong T K, Lee D W, Choi H J, Shin H S, Kim B S. ACS Nano, 2010, 4(7): 3861-3868
56. [56]
  56 Jafri R I, Arockiados T, Rajalakshmi N, Ramaprabhu S. J. The Electrochem. Soc., 2010, 157(6): B874-B879
57. [57]
  57 Wang K, Liu Q, Guan Q M, Wu J, Li H N, Yan J J. Biosens. Bioelectron., 2011, 26(5): 2252-2257
58. [58]
  58 Wan Y, Wang Y, Wu J, Zhang D. Anal. Chem., 2010, 83(3): 648-653
59. [59]
  59 Bo Y, Yang H, Hu Y, Yao T, Huang S. Electrochim. Acta, 2011, 56(6): 2676-2681
60. [60]
  60 Wang Y, Li Y, Tang L, Lu J, Li J. Electrochem. Commun., 2009, 11(4): 889-892
61. [61]
  61 Xu H, Dai H, Chen G. Talanta, 2010, 81(1-2): 334-338
62. [62]
  62 Shan C, Yang H, Han D, Zhang Q, Ivaska A, Niu L. Biosens. Bioelectron., 2010, 25(5): 1070-1074
63. [63]
  63 Wu H, Wang J, Kang X, Wang C, Wang D, Liu J, Aksay I A, Lin Y. Talanta, 2009, 80(1): 403-406
64. [64]
  64 Wu Z S, Ren W, Gao L, Liu B, Jiang C, Cheng H M. Carbon, 2009, 47(2): 493-499
65. [65]
  65 Zhong Z, Wu W, Wang D, Wang D, Shan J, Qing Y, Zhang Z. Biosens. Bioelectron., 2010, 25(10): 2379-2383
66. [66]
  66 Feng L, Chen Y, Ren J, Qu X. Biomaterials, 2011, 32(11): 2930-2937
67. [67]
  67 Shan C, Yang H, Song J, Han D, Ivaska A, Niu L. Anal. Chem., 2009, 81(6): 2378-2382
68. [68]
  68 Hou S, Kasner ML, Su S, Patel K, Cuellari R. J. Phys. Chem. C, 2010, 114(35): 14915-14921
69. [69]
  69 Li F, Chai J, Yang H, Han D, Niu L. Talanta, 2010, 81(3): 1063-1068
70. [70]
  70 Huang Y, Chen Y S. Sci. China Ser. B: Chem., 2009, 39(9): 887-896
71. [71]
  71 Arsat R, Breedon M, Shafiei M, Spizziri P G, Gilje S, Kaner R B, Kalantar-zadeh K, Wlodarski W. Chem. Phys. Lett., 2009, 467(4-6): 344-347
72. [72]
  72 Meyer J C, Geim A K, Katsnelson M I, Novoselov K S, Booth T J, Roth S. Chem. Commun., 2007, 446(7131): 60-63
73. [73]
  73 Wang X, Ouyang Y, Li X, Wang H, Guo J, Dai H. Phys. Rev. Lett., 2008, 100(20): 206803
74. [74]
  74 Son Y W, Cohen M L, Louie S G. Chem. Commun., 2006, 444(7117): 347-349
75. [75]
  75 Avouris P, Chen Z, Perebeinos V. Nat. Nano., 2007, 2(10): 605-615
76. [76]
  76 Song B, Li D, Qi W, Elstner M, Fan C, Fang H. ChemPhysChem., 2010, 11(3): 585-589
77. [77]
  77 Lu C H, Yang H H, Zhu C L, Chen X, Chen G N. Angew. Chem. Int. Edit., 2009, 48(26): 4785-4787
78. [78]
  78 Liu C, Wang Z, Jia H, Li Z. Chem. Commun., 2011, 47(16): 4661-4663
79. [79]
  79 He S, Song B, Li D, Zhu C, Qi W, Wen Y, Wang L, Song S, Fang H, Fan C. Adv. Funct. Mater., 2010, 20(3): 453-459
80. [80]
  80 Zhang M, Yin B C, Tan W, Ye B C. Biosens. Bioelectron., 2011, 26(7): 3260-3265
81. [81]
  81 Lu C H, Li J, Liu J J, Yang H H, Chen X, Chen G N. Chemistry-A European Journal, 2010, 16(16): 4889-4894
82. [82]
  82 Liu M, Zhang Q, Zhao H, Chen S, Yu H, Zhang Y, Quan X. Chem. Commun., 2011, 47(14): 4084-4086
83. [83]
  83 Tang Z, Wu H, Cort J R, Buchko G W, Zhang Y, Shao Y, Aksay I A, Liu J, Lin Y. Small, 2010, 6(11): 1205-1209
84. [84]
  84 Guo Y, Jia X, Zhang S. Chem. Commun., 2011, 47(2): 725-727
85. [85]
  85 Fan F R, Park S, Zhu Y, Ruoff R S, Bard A J. J. Am. Chem. Soc., 2008, 131(3): 937-939
86. [86]
  86 Wang Y, Lu J, Tang L, Chang H, Li J. Anal. Chem., 2009, 81(23): 9710-9715
87. [87]
  87 Wang K, Liu Q, Wu X Y, Guan Q M, Li H N. Talanta, 2010, 82(1): 372-376
88. [88]
  88 Li H, Chen J, Han S, Niu W, Liu X, Xu G. Talanta, 2009, 79(2): 165-170
89. [89]
  89 Chen X, Ye H, Wang W, Qiu B, Lin Z, Chen G. Electroanalysis, 2010, 22(20): 2347-2352
90. [90]
  90 Chen G, Zhai S, Zhai Y, Zhang K, Yue Q, Wang L, Zhao J, Wang H, Liu J, Jia J. Biosens. Bioelectron., 2011, 26(7): 3136-3141
91. [91]
  91 Gan N, Hou J, Hu F, Cao Y, Li T, Zheng L, Wang J. Int. J. Electrochem. Sci., 2011, 6(11): 5146-5160
92. [92]
  92 Li L L, Liu K P, Yang G H, Wang C M, Zhang J R, Zhu J J. Adv. Funct. Mater., 2011, 21(5): 869-878
93. [93]
  93 Kim Y T, Han J H, Hong B H, Kwon Y U. Adv. Mater., 2010, 22(4): 515-518
94. [94]
  94 Wang T, Zhang S, Mao C, Song J, Niu H, Jin B, Tian Y. Biosens. Bioelectron., 2012, 31(1): 369-375
95. [95]
  95 Cao A, Liu Z, Chu S, Wu M, Ye Z, Cai Z, Chang Y, Wang S, Gong Q, Liu Y. Adv. Mater., 2010, 22(1): 103-106
96. [96]
  96 Geng X, Niu L, Xing Z, Song R, Liu G, Sun M, Cheng G, Zhong H, Liu Z, Zhang Z, Sun L, Xu H, Lu L, Liu L. Adv. Mater., 2010, 22(5): 638-642
97. [97]
  97 Zhou M, Wang Y, Zhai Y, Zhai J, Ren W, Wang F, Dong S. Chemistry-A European Journal, 2009, 15(25): 6116-6120
98. [98]
  98 Deng S, Lei J, Cheng L, Zhang Y, Ju H. Biosens. Bioelectron., 2011, 26(11): 4552-4558
99. [99]
  99 Yuan Y, Li H, Han S, Hu L, Parveen S, Cai H, Xu G. Anal. Chem. Acta, 2012, 720: 38-42
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