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Citation: YANG Xiaoci, REN Jie, YAO Mengqi, ZHANG Xiaoyan, YANG Wu. Controlled Drug Release Behaviors of ChitosanPoly(acrylic acid) Composite Hydrogels[J]. Chinese Journal of Applied Chemistry, ;2014, 31(10): 1143-1148. doi: 10.3724/SP.J.1095.2014.30659 shu

Controlled Drug Release Behaviors of ChitosanPoly(acrylic acid) Composite Hydrogels

1.
College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China

Corresponding author: REN Jie,
Received Date: 24 December 2013
Available Online: 18 February 2014
Fund Project: 甘肃省高校基本科研业务费基金资助项目(5001-109) (5001-109)

The chitosan(Cs) and acrylic acid(AA) were used to prepare the composite hydrogel(Cs-PAA) by radical polymerization method. The influences of reaction temperature, neutralization degree of acrylic acid, amounts of cross-linking agent and acrylic acid on the swelling degree of the composite hydrogels were investigated. In addition, the controlled release behaviors of prepared hydrogels for niacin were evaluated. The swelling degree of prepared hydrogels is up to 1228 g/g. It exhibits excellent pH and ionic strength sensitivity. The cumulative release rate in a pH=6.86 buffer solution is significantly higher than that in a pH=1.8 buffer solution. Therefore, the hydrogels can be used as carriers of intestinal oral drugs.
- composite hydrogel,
- swelling degree,
- drug release,
- niacin
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