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Citation: LIU Daxing, WANG Mingzhe, JING Xiabin, HUANG Yubin. Improved Suvival Quality of Mice with Cervical Cancer Through the Therapy of Sodium Dichloroacetateloaded Electrospun Mats[J]. Chinese Journal of Applied Chemistry, ;2014, 31(7): 763-769. doi: 10.3724/SP.J.1095.2014.30537 shu

Improved Suvival Quality of Mice with Cervical Cancer Through the Therapy of Sodium Dichloroacetateloaded Electrospun Mats

1.
a Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
2.
b University of Chinese Academy of Sciences, Beijing 100049, China

Corresponding author: HUANG Yubin,
Received Date: 31 October 2013
Available Online: 10 December 2013
Fund Project: 国家自然科学基金(51273194,51021003,50733003,21174143) (51273194,51021003,50733003,21174143)吉林省科技厅项目(20100588)资助 (20100588)

Solidum dichloroacetate(DCA) loaded electrospun mats was fabricated through the solution electrospun method.When applying this DCA-loaded electrospun mats on the therapy of the subcutaneous cervical cancer model,a 94% tumor suppression rate and an overall 38% recovery rate were achieved after 19 days' treatment.The trend of recurrence and metastasis was also significantly inhabited.Meanwhile,DCA-loaded electropsun mats improved the life quality of tumor-bearing mice fundamentally.Therefore,DCA administrated by electrospun mats is a safe approach for the treatment of anti-cervical cancer.
- cervical cancer,
- sodium dichloroacetate,
- electropsun mats,
- suvivial quality
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