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Citation: YU Jiangxi, FENG Yonglan, KUANG Daizhi, ZHANG Fuxing, JIANG Wujiu, ZHU Xiaoming. Microwave Assisted Synthesis,Structural Characterization,Thermal Stability and in vitro Anticancer Activity of Tricyclohexyltin 8-Quinolinoxide[J]. Chinese Journal of Applied Chemistry, ;2014, 31(8): 937-942. doi: 10.3724/SP.J.1095.2014.30495 shu

Microwave Assisted Synthesis,Structural Characterization,Thermal Stability and in vitro Anticancer Activity of Tricyclohexyltin 8-Quinolinoxide

1.
Key Laboratory of Functional Organometallic Materials of College of Hunan Province, Department of Chemistry and Material Science, Hengyang Normal University, Hengyang 421008, China

Corresponding author: KUANG Daizhi,
Received Date: 8 October 2013
Available Online: 9 January 2014
Fund Project: 湖南省自然科学基金(13JJ3112) (13JJ3112)湖南省科技计划(2013TZ2025,2014NK3086) (2013TZ2025,2014NK3086)湖南省高校创新平台开放基金(13K105) (13K105)教育厅一般项目(12C0537) (12C0537)衡阳市科技计划(2011KG56,2012KJ30) (2011KG56,2012KJ30)衡阳师范学院协同创新中心培育项目(12XT02) (12XT02)衡阳师范学院青年骨干教师培养计划(2012)资助 (2012)

A novel tricyclohexyltin complex Cy₃SnOC₉NH₆ was synthesized by the reaction of 8-quinolinol with tricyclohexyltin hydroxide under microwave irradiation,and characterized by UV,IR,¹H and ¹³C NMR,elemental analysis and X-ray crystal diffraction. The crystal belongs to triclinic system,space group P1 with the cell parameters:a=0.99530(5) nm,b=1.01129(5) nm,c=2.58327(13) nm,α=89.1880(10)°,β=86.6290(10)°,γ=81.2490(10)°,Z=4,V=2.5654(2) nm³,D_c=1.326 Mg/m³,μ(MoKα)=1.013 mm^-1,F(000)=1064,R₁=0.0447,wR₂=0.0891. The complex is stable up to ~200℃. It displays strong in vitro anticancer activity against four human cancer cell lines,Colo205,HepG2,MCF-7 and NCI-H460.
- tricyclohexyltin 8-quinolinol complex,
- microwave assisted synthesis,
- crystal structure,
- anticancer activity
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