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Citation: JIN Chao, FU Hualin, ZHANG Wei, ZHANG Yanli, CAO Hang, ZHOU Tao, LU Chaocheng, LIU Mengjiao, ZHOU Jianyu. Synthesis of the Twin Drug of Ibuprofen and Paracetamol[J]. Chinese Journal of Applied Chemistry, ;2014, 31(7): 782-787. doi: 10.3724/SP.J.1095.2014.30430 shu

Synthesis of the Twin Drug of Ibuprofen and Paracetamol

JIN Chao ^a ,
FU Hualin ^a,b,, ,
ZHANG Wei ^a ,
ZHANG Yanli ^a ,
CAO Hang ^a ,
ZHOU Tao ^a ,
LU Chaocheng ^a ,
LIU Mengjiao ^a ,
ZHOU Jianyu ^a

1.
a Department of Pharmacy, Sichuan Agricultural University, Ya'an 625014, China;
2.
b Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China

Corresponding author: FU Hualin,
Received Date: 27 August 2013
Available Online: 16 December 2013
Fund Project: 教育部"长江学者和创新团队发展计划"创新团队项目(IRT0848) (IRT0848)

The twin drug(PHI) was synthesized by coupling ibuprofen(IPF) and paracetamol(PCM) using dicyclohexylcarbodiimide(DCC) as dehydrating agent,4-dimethylaminopyridine(DMAP) as catalyst,and anhydrous acetone and ethyl acetate as reaction solvents.PHI was purified by recrystallization and its structure was confirmed by IR and ¹H NMR spectroscopy.The effect of catalyst,dehydrating agent,reaction time,feed ratio and reaction solvents on the yield of the product was investigated.The reaction conditions were optimized by the orthogonal test.The optimized reaction conditions are:the molar ratio of raw materials is n(PCM):n(IPF)=1:1.5,the optimal amount of DMAP is 10% mass fraction of ibuprofen;the volume of solvent is 70 mL(the volume ratio of ethyl acetate and acetone is 1:1) and the reaction time is 8 h.Under the optimized conditions,the yield of target is 66.5%.
- Ibuprofen,
- paracetamol,
- twin drug,
- dicyclohexylcarbodiimide/dimethylaminopyridine
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