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Citation: LIN Mei, LIN Meiyu, ZHU Wei, LI Chaoping, CHEN Hebi, GAO Fan, WU Shanyue, HUANG Yixuan. Preparation of Cationic Polyvinylpyrrolidone and Its Loading Property to RNA[J]. Chinese Journal of Applied Chemistry, ;2014, 31(6): 649-653. doi: 10.3724/SP.J.1095.2014.30421 shu

Preparation of Cationic Polyvinylpyrrolidone and Its Loading Property to RNA

LIN Mei ^a,, ,
LIN Meiyu ^b ,
ZHU Wei ^a ,
LI Chaoping ^a ,
CHEN Hebi ^a ,
GAO Fan ^a ,
WU Shanyue ^a ,
HUANG Yixuan ^a

1.
a Department of Medicinal Chemistry, School of Pharmacy, Fujian Medical University, Minhou 350108, China;
2.
b Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China

Corresponding author: LIN Mei,
Received Date: 21 August 2013
Available Online: 30 September 2013
Fund Project: 福建省青年人才创新基金资助项目(2008F3049) (2008F3049)福建省大学生创新实验基金资助项目(201310392081) (201310392081)

Cationic polyvinylpyrrolidone(CPVP) was synthesized by copolymerization of diallyldimethyl ammonium chloride(DADMAC) and vinylpyrrolidone(VP).Polydiallyldimethyl ammonium chloride(PDADMAC) and polyvinylpyrrolidone(PVP) were also synthesized.Their viscosity-average relative molecular masses were measured by viscometry and their structures were characterized by Fourier transform infrared spectroscopy(FTIR).CPVP,PDADMAC and PVP were mixed with ribonucleic acid(RNA) in different ratios in order to measure their loading property.The results indicate that the composite nanoparticles formed by mixing CPVP and RNA with a mass ratio of 2:1 are about 300 nm with a polydistribution index of 0.0966 and the size distribution of nanoparticles is narrower than those of PVP and PDADMAC.
- cationic,
- polyvinylpyrrolidone,
- ribonucleic acid,
- nanoparticle
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