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Citation: YANG Weicheng, QI Qingrui, LI Meihua, YANG Chao, LUO Yong. Synthesis and Characterization of Stabe Isotope Deuterium-labeled D₆-Crystal Violet[J]. Chinese Journal of Applied Chemistry, ;2014, 31(3): 262-267. doi: 10.3724/SP.J.1095.2014.30218 shu

Synthesis and Characterization of Stabe Isotope Deuterium-labeled D₆-Crystal Violet

YANG Weicheng ^a ,
QI Qingrui ^b ,
LI Meihua ^a ,
YANG Chao ^a ,
LUO Yong ^a,,

1.
a Research & Development Center, Shanghai Research Institute of Chemical Industry, Shanghai 200062, China;
2.
b Branch of Professional Technique, Xinjiang Normal University, Urumqi 830063, China

Corresponding author: LUO Yong,
Received Date: 6 May 2013
Available Online: 10 July 2013
Fund Project: 科技部转制院所专项(2012EG116257) (2012EG116257)长三角科技联合攻关项目(10595812100) (10595812100)质检公益性行业科研专项项目计划(201310140) (201310140)

An efficient synthesis of deuterium labeled crystal violet[D₆]with CD₃OD as the common substrate was developed via esterification,N-methylation and condensation.Taking advantage of the uniform design method,the effects of feed ratio,the amount of phosphorus oxychloride,reaction temperature and reaction time on the yield of crystal violet were investigated.The optimized reaction parameters were found by using quadratic polynomial regression analysis based on the data obtained from experiments.The target product was characterized by MS,NMR and HPLC.Its chemical purities is higher than 98.0% and isotopic enrichment is higher than 99.5%(atom D).This product could be used as an internal standard in the field of food safety.
- stabe isotope-labelling,
- crystal violet,
- uniform design,
- characterization
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Synthesis and Characterization of Stabe Isotope Deuterium-labeled D6-Crystal Violet

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Synthesis and Characterization of Stabe Isotope Deuterium-labeled D₆-Crystal Violet