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Citation: LIU Tao, WEI Dong, JIANG Bo, XU Guoyong, ZHOU Shuangsheng. Synthesis,Characterization and Antitumor Activities of Cu(Ⅱ)-Aspirin Complex[J]. Chinese Journal of Applied Chemistry, ;2014, 31(3): 296-302. doi: 10.3724/SP.J.1095.2014.30202 shu

Synthesis,Characterization and Antitumor Activities of Cu(Ⅱ)-Aspirin Complex

LIU Tao ^a ,
WEI Dong ^a ,
JIANG Bo ^a ,
XU Guoyong ^b ,
ZHOU Shuangsheng ^a,b,,

1.
a Department of Pharmacy, Anhui College of Traditional Chinese Medicine, Hefei 230031, China;
2.
b Center of Modern Experimental Technology, Anhui University, Hefei 230039, China

Corresponding author: ZHOU Shuangsheng,
Received Date: 24 April 2013
Available Online: 16 July 2013
Fund Project: 国家自然科学基金(21071001) (21071001)安徽省自然科学基金(1208085MH273)资助项目 (1208085MH273)

A Cu(Ⅱ)-aspirin complex has been synthesized and characterized by IR spectroscopy and single crystal X-ray diffraction analyses.The complex crystallizes in monoclinic space group P2₁/n with cell parameters of a=8.211(5) nm,b=10.419(5) nm,c=21.003(5) nm,β=98.021(5)°,V=1779.2(14) nm³,Z=4.The interactions of the complex with ct-DNA were studied by UV,fluorescence spectroscopy and cyclic voltammetry method.At the same time,the antitumor activities of the complex against MCF-7 and MGC-803 cell lines were tested by MTT assay.The in vitro inhibitory ratios against two tumor cell lines are 80.01% and 70.16% at concentration of 120 μmol/L,respectively.
- Cu(Ⅱ)-aspirin complex,
- crystal structure,
- antitumor activity,
- ct-DNA,
- interaction
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