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Citation: ZHAO Guiyan, XU Jingwei, YANG Wei. Synthesis and Relaxation Properties of a Binuclear Gadolinium(Ⅲ) Polyaminocarboxylates Magnetic Resonance Imaging Contrast Agent[J]. Chinese Journal of Applied Chemistry, ;2014, 31(2): 225-230. doi: 10.3724/SP.J.1095.2014.30156 shu

Synthesis and Relaxation Properties of a Binuclear Gadolinium(Ⅲ) Polyaminocarboxylates Magnetic Resonance Imaging Contrast Agent

ZHAO Guiyan ^a,b ,
XU Jingwei ^a,, ,
YANG Wei ^a,,

1.
a The State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
2.
b University of the Chinese Academy of Sciences, Beijing 100049, China

Corresponding author: XU Jingwei, YANG Wei,
Received Date: 1 April 2013
Available Online: 23 April 2013
Fund Project: 国家自然科学基金资助项目(30870491) (30870491)

A binuclear gadolinium(Ⅲ) complex,[Gd₂(TP(DTTA)₂)(H₂O)₄]^2-,containing two DTTAGd paramagnetic units(DTTA=diethylenetriamine-N,N,N",N"-tetraacetate) bridged by a terephthaloyl(TP) core has been synthesized and evaluated as a potential magnetic resonance imaging(MRI) contrast agent.The relaxation measurements indicate that the dinuclear gadolinium(Ⅲ) complex has a much higher relaxivity than that of the previously reported dinuclear DTTA-based agent(21.7 L/(mmol·s) per Gd³⁺ vs 12.8 L/(mmol·s) at 20 MHz,37℃ and pH=7).Moreover,the luminescence lifetime measurements on the analogue terbium Tb₂(TP(DTTA)₂) give the inner-sphere hydration number of q=1.4.The results show that a more rigid linker in dinuclear MRI contrast agents is helpful for relaxivity improvement.
- magnetic resonance imaging,
- multinuclear contrast agents,
- high relaxivity,
- rigid linker,
- Gd-DTTA
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