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Citation: GUO Danli, ZHANG Hua, HU Qiuyun, CAI Sanyan, CHEN Ziyun, WENG Wen. Preparation and Evaluation of Several Cellulose Ester-Coated Chiral Stationary Phases with Different Supports[J]. Chinese Journal of Applied Chemistry, ;2013, 30(10): 1231-1236. doi: 10.3724/SP.J.1095.2013.30067 shu

Preparation and Evaluation of Several Cellulose Ester-Coated Chiral Stationary Phases with Different Supports

Department of Chemistry and Environmental Science, Zhangzhou Normal University, Zhangzhou 363000, China

Received Date: 28 January 2013
Revised Date: 4 March 2013

Cellulose tris(3,5-dimethylphenylcarbamate)(CDMPC) was prepared from cellulose and 3,5-dimethylphenyl isocyanate.Then the product was coated onto three supports,i.e.small-pore silica gel(SG),aminopropylsilylated silica gel(APS-SG),and mesoporous silica SBA-15.The obtained chiral stationary phases(CSPs) were denoted as SG@CDMPC(CSP1),APS-SG@CDMPC(CSP2),and SBA-15@CDMPC(CSP3).Twelve neutral or acidic compounds were enantioseparated with these three homemade CSPs in the normal phase mode.The results were compared with enantioseparation using the commercial CSP,Chiralcel OD-H.Six compounds are obtained with a better column efficiency on CSP1 than that on Chiralcel OD-H,and two of them are obtained with a better enantioseparation.The enantioseparation ability is poorer on CSP2 and CSP3 than those on CSP1 and the commercial column in general.Enantioseparation and quantitative determination of warfarin were performed on the homemade CSPs.The limit of detection(LOD) is 10 μg/L for warfarin on CSP1.The linear calibration curve is obtained in the concentration range of 0.05~5.0 g/L.
- liquid chromatography,
- enantioseparation,
- cellulose ester derivative,
- small-pore silica gel,
- mesoporous silica SBA-15
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