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Citation: LIU Rong, ZHONG Tongsheng, LONG Liping, YIN Zhifang, CAO Wei. Fabrication and Application of Chlorpromazine Molecular Imprinting Film Sensor[J]. Chinese Journal of Applied Chemistry, ;2013, 30(11): 1361-1365. doi: 10.3724/SP.J.1095.2013.30030 shu

Fabrication and Application of Chlorpromazine Molecular Imprinting Film Sensor

College of Chemistry & Environmental Engineering, Hunan City University, Yiyang 413000, China

Received Date: 11 January 2013
Revised Date: 11 March 2013

A sensitive chlorpromazine sensor based on molecularly imprinted membrane(MIP) was fabricated with chlorpromazine as template molecule and o-aminophenol as functional monomers. The performance of MIP and the electrochemical behavior of molecular imprinted sensor were obtained by cyclic voltammetry(CV) and differential pulse voltammetry(DPV). The sensor exhibits good selectivity and sensitivity for measuring chlorpromazine compared with the structurally-related compounds of promethazine and perphenazine. The linear relationship between the peak current and chlorpromazine concentration is found at the range of 6.0 × 10^-7~9.0 × 10^-5 mol/L,the liner equation is I(μA)=61.25lg c(μmol/L) + 23.47(r=0.9975),the limit of detection is 2.0 × 10^-7 mol/L. This sensor has many advantages such as high sensitivity,good reproducibility and repeatability.
- chlorpromazine,
- molecularly imprinting,
- electrochemical sensor,
- electropolymerization
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