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Citation: HE Jinmei, QU Mengnan, HE Zhongsen. One Pot Continuous Reaction of Benzoin Condensation and Allylic Nucleophilic Substitution Using N-Heterocyclic Carbenes and Nickel(Ⅱ) Chloride as Catalysts[J]. Chinese Journal of Applied Chemistry, ;2013, 30(7): 852-854. doi: 10.3724/SP.J.1095.2013.20527 shu

One Pot Continuous Reaction of Benzoin Condensation and Allylic Nucleophilic Substitution Using N-Heterocyclic Carbenes and Nickel(Ⅱ) Chloride as Catalysts

College of Chemistry and Chemical Engineering, Xi'an University of Science and Technology, Xi'an 710054, China

Received Date: 15 November 2012
Revised Date: 13 December 2012

With the presence of nickel(Ⅱ) chloride as metal complex catalyst and N-heterocyclic carbene as organic catalyst effective one pot synthesis of allylated α-hydroxy carbonyl compound in 78% yield was developed using benzaldehyde and cinnamyl acetate as precursors in potassium carbonate THF solution. The involved reactions during the continuous reaction are benzoin condensation and allylic nucleophilic substitution.
- nickel(Ⅱ) chloride,
- N-heterocyclic carbenes,
- catalyze,
- one pot,
- benzoin condensation,
- allylic nucleophilic substitution
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