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Citation: SUN Xinzhi, MA Chuanli. Preparation and Antimicrobial Activity of Thiourea Chitosan-Ag⁺ Complex[J]. Chinese Journal of Applied Chemistry, ;2013, 30(6): 633-637. doi: 10.3724/SP.J.1095.2013.20356 shu

Preparation and Antimicrobial Activity of Thiourea Chitosan-Ag⁺ Complex

SUN Xinzhi ,
MA Chuanli

College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, China

Received Date: 17 August 2012
Revised Date: 22 October 2012

Thiourea(TU) chitosan(CTS)-Ag⁺ complex was prepared by the reaction of thiourea chitosan with a trace amount of silver ion in homogeneous solution,and was characterized by FT-IR. Antimicrobial activities of CTS,TU-CTS,TU-CTS-Ag⁺ complex and AgNO₃ were evaluated against E.coli and S.aureus in vitro,and the minimum inhibition concentration(MIC) and the minimum bactericidal concentration(MBC) were determined. The results show that the complex has stronger antimicrobial activities than chitosan and thiourea chitosan. The MIC and MBC of thiourea chitosan Ag⁺ complex are both 100 mg/L (free silver ion content 0.032 mg/L),lower than the MIC and MBC for AgNO₃,which are both 120 g/L.
- chitosan,
- thiourea chitosan,
- antimicrobial activity,
- trace amounts of silver ion
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Preparation and Antimicrobial Activity of Thiourea Chitosan-Ag⁺ Complex