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Citation: GAN Chunfang, SU Shaoyang, HUANG Yanmin, LIN Qifu, CUI Jianguo. Synthesis and Antiproliferative Activity of 3-Substituted-12oxy-N,N-bis(2-chloroethyl)-7-deoxycholic Amides[J]. Chinese Journal of Applied Chemistry, ;2013, 30(6): 628-632. doi: 10.3724/SP.J.1095.2013.20352 shu

Synthesis and Antiproliferative Activity of 3-Substituted-12oxy-N,N-bis(2-chloroethyl)-7-deoxycholic Amides

a. College of Chemistry and Life Science, Guangxi Teachers Education University, Nanning 530001, China;
b. Guangxi Special Equipment Supervision and Inspection Institute, Nanning 530219, China

Received Date: 16 August 2012
Revised Date: 9 November 2012

Using 7-deoxycholic acid(1) as a starting material,3,12-dioxy-7-deoxycholic acid(2) was obtained by oxidation with Jones reagent. Then the N,N-bis(2-chloroethyl)-3,12-dioxy-7-deoxycholic amide(4) was synthesized by the reaction of compound 2 with bis(2-chloroethyl) amine. Furthermore,N,N-bis(2chloroethyl)-12-oxy-3-hydroximino-7-deoxycholic amide (5) and N,N-bis(2-chloroethyl)-12-oxy-3thiosemicarbazone-7-deoxycholic amide(6) were prepared by the functional group transformation of 3-carbonyl on compound 4. The antiproliferative activities of compounds against HeLa cells were assayed and the result showed that the compounds displayed distinct cytotoxicity.
- deoxycholic acid,
- substituted-oxy-N,N-bis(chloroethyl)-deoxycholic amides,
- synthesis,
- cytotoxicity
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