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Citation: SHI Lanxiang, ZHANG Baohu. New Method for Synthesizing O-Desmethylvenlafaxine[J]. Chinese Journal of Applied Chemistry, ;2013, 30(5): 608-610. doi: 10.3724/SP.J.1095.2013.20351 shu

New Method for Synthesizing O-Desmethylvenlafaxine

College of Chemical Engineering, Shijiazhuang University, Shijiazhuang 050035, China

Received Date: 15 August 2012
Revised Date: 13 September 2012

The O-desmethylvenlafaxines were prepared from venlafaxine reacted with new demethylation reagents cysteine sodium and sodium penicillamine,respectively.The corresponding yields are 86% and 82%,respectively.Since the synthesis could be fulfilled in a one-pot approach by mixing cysteine sodium salt,sodium penicillamine preparation and venlafaxine demethylation together,the reaction was fairly simplified.The optimal reaction conditions are:N-methyl pyrrolidone as the solvent,reaction temperature of 175℃ and the pH value of 9.5 for product to crystallize.
- O-desmethylvenlafaxine,
- venlafaxine,
- demethylation,
- cysteine sodium,
- sodium penicillamine
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