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Citation: GUO Wenyan, ZHAO Minggang, HAO Aiyou. Synthesis of Amphiphilic β-Cyclodextrins and Their Nanospheres in Water[J]. Chinese Journal of Applied Chemistry, ;2013, 30(3): 260-264. doi: 10.3724/SP.J.1095.2013.20164 shu

Synthesis of Amphiphilic β-Cyclodextrins and Their Nanospheres in Water

a. School of Chemistry and Materials Science, Shanxi Normal University, Linfen 041004, China;
b. Modern College of Arts and Science of Shanxi Normal University, Linfen 041000, China;
c. School of Chemistry and Chemical Engineering, Shandong University, Ji'nan 250100, China

Received Date: 19 April 2012
Revised Date: 13 June 2012

Four amphiphilic bifunctionalized β-cyclodextrin derivatives with low degree of substitution(DS) were conveniently synthesized via the reaction of 2-O-(2-hydroxypropyl)-β-cyclodextrin with Lauryl glycidol ether,tetradecyl glycidol ether,hexadecyl glycidol ether and octadecyl glycidol ether in pyridine,respectively.The four amphiphilic β-CD derivatives(DS 1.87,1.95,2.14 and 1.80,respectively) could self-assemble in water to form stable nanospheres with improved dispersion degree and uniformity up to 2~3 weeks.
- amphiphilic,
- O-(hydroxypropyl)-β-cyclodextrin,
- glycidol ether,
- nanospheres
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