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Citation: HAN Junxing, LIU Yanqin, HAN Shitian. Synthesis of m-Chlorophenyl Mn-Porphyrin-5-Fluorouracil Complexes and Their Inhibition Activity to Cancer Cells[J]. Chinese Journal of Applied Chemistry, ;2012, 29(6): 718-720. doi: 10.3724/SP.J.1095.2012.00354 shu

Synthesis of m-Chlorophenyl Mn-Porphyrin-5-Fluorouracil Complexes and Their Inhibition Activity to Cancer Cells

1.
College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050024, China

Corresponding author: LIU Yanqin,
Received Date: 15 August 2011
Available Online: 21 October 2011
Fund Project: 河北省自然科学基金(203147)资助项目 (203147)

Four porphyrin-5-fluorouracil conjugates,i.e.5-[3-(2-(5-fluorouracil-1-yl)-ethoxy)phenyl]-10,15,20-tri(3-chlorophenyl)porphyrin(1a),5-[3-(2-(5-fluorouracil-1-yl)-ethoxy)phenyl]-10,15,20-tri(3-chlorophenyl)Mn-porphyrin(2a),5-[3-(3-(5-fluorouracil-1-yl)-propoxy)phenyl]-10,15,20-tri(3-chlorophenyl)Mn-porphyrin(2b) and 5-[3-(4-(5-fluorouracil-1-yl)-butoxy)phenyl]-10,15,20-tri(3-chlorophenyl)Mn-porphyrin(2c),were successfully synthesized and characterized by UV-Vis,IR,MS and elemental analysis.Inhibition activity of the synthesized compounds(2a,2b and 2c) to human gastric cancer cell line BGC-823 was tested using the methyl thiazolyl tetrazolium(MTT) method.The IC₅₀ value of 2b was 1.34 μmol/L,indicating that compound 2b had certain cytotoxic effect.
- manganoporphyrin,
- fluorouracil,
- synthesis,
- human gastric cancer cell line BGC-823
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