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Citation: LU Hongfei, WU Dingming, SUN Leilei, GAO Yuhua. Synthesis of O⁶-Substituted Purine Derivatives Catalyzed by 4-Amino-pyridine[J]. Chinese Journal of Applied Chemistry, ;2012, 29(4): 402-409. doi: 10.3724/SP.J.1095.2012.00251 shu

Synthesis of O⁶-Substituted Purine Derivatives Catalyzed by 4-Amino-pyridine

1.
School of Biological and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, China

Corresponding author: LU Hongfei,
Received Date: 14 June 2011
Available Online: 1 September 2011
Fund Project: 江苏省自然科学基金(BK2009721) (BK2009721)江苏科技大学青年骨干教师支持计划(37060902)资助项目 (37060902)

A series of O⁶-substituted purine derivatives was designed and prepared through an efficient and convenient method with 4-amino-pyridine as the catalyst in methanol solvent.Under optimized conditions:n(6-chloropurine):n(4-amino-pyridine):n(triethylamine)=10:1:4,refluxing for 5~7 h,the yield of 6-alkoxy purine was greater than 85%.Studies showed that,the relative amount of 6-chloropurine,4-amino-pyridine and triethylamine in the system had a great influence on the reaction,and the highest catalytic activity was achieved using a mixture of 4-amino-pyridine and triethylamine as the catalyst.
- amino-pyridines,
- purine,
- catalyst,
- oxyalkylation,
- synthesis
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Synthesis of O6-Substituted Purine Derivatives Catalyzed by 4-Amino-pyridine

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Synthesis of O⁶-Substituted Purine Derivatives Catalyzed by 4-Amino-pyridine