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Citation: SHENG Zecui, ZHOU Cheng, ZHANG Lingzhi, ZHU Liangliang, JIANG Bo, CHEN Yingwen, ZHU Shemin, SHEN Shubao. Solid-phase Synthesis of Eptifibatide in a Multifunctional Reactor[J]. Chinese Journal of Applied Chemistry, ;2012, 29(3): 275-279. doi: 10.3724/SP.J.1095.2012.00205 shu

Solid-phase Synthesis of Eptifibatide in a Multifunctional Reactor

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a College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009, China;
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b College of Material Science and Engineering, Nanjing University of Technology, Nanjing 210009, China;
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c Chemistry and Chemical Engineering Department, Xuzhou Normal University, Xuzhou 221116, China

Corresponding author: SHEN Shubao,
Received Date: 16 May 2011
Available Online: 13 July 2011
Fund Project: 国家863资助项目(2009AA05Z313,2006AA02Z211) (2009AA05Z313,2006AA02Z211)国家自然科学基金资助项目(50872052,20376034) (50872052,20376034)江苏省自然科学基金资助项目(BK2006181) (BK2006181)江苏省高校研究生创新计划资助项目(2007) (2007)江苏省环保厅资助项目(2009002) (2009002)江苏省科技厅资助项目(BE2010196) (BE2010196)

A home-made reactor possessing functions including reaction,blending,bubbling,protecting with N₂ and filtration was fabricated.The effects of the type of resin,solvent,coupling reagent and reaction time on the yield of cyclic eptifibatide were investigated.The results showed the overall yield was up to 86.6%,using Rink Amide AM resin as solid supporter,HBTU/HOBt/DIEA as the coupling reagent,DMF as the solvent and reaction 2 hours in the reactor.The purity of the product as revealed by HPLC could reach 98%.
- Eptifibatide,
- solid-phase synthesis reactor,
- Fmoc method
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