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Citation: WAN Li, CAI Chun. Synthesis and Application of A Fluorous Proline-derived Ligand in the Copper(Ⅱ)-catalyzed Henry Reaction[J]. Chinese Journal of Applied Chemistry, ;2012, 29(2): 140-143. doi: 10.3724/SP.J.1095.2012.00119 shu

Synthesis and Application of A Fluorous Proline-derived Ligand in the Copper(Ⅱ)-catalyzed Henry Reaction

WAN Li ^a ,
CAI Chun ^a,b,,

1.
a Chemical Engineering College, Nanjing University of Science & Technology, Nanjing 210094, China;
2.
b Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Corresponding author: CAI Chun,
Received Date: 25 March 2011
Available Online: 26 May 2011
Fund Project: 南京理工大学自主科研基金(2010ZDJH14)资助项目 (2010ZDJH14)

A new fluorous proline-derived ligand has been synthesized and applied to the copper-catalyzed Henry reaction.The reaction conditions were optimized in terms of ligand,Cu source,solvent and base taking the reaction of 4-nitrobenzaldehyde and nitromethane as a model reaction.The optimized conditions are:using fluorous proline imide as ligand,copper acetate as copper source,methanol as solvent and triethylamine as base and the reaction was carried out at room temperature.A wide range of substrates were investigated under the optimized conditions and the yields of the target products varied from 53% to 98%.
- β-niroalcohols,
- Henry reaction,
- fluorous proline ligand,
- copper catalyst
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