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Citation: PAN Dengke, ZHANG Hui, MU Yuanhua. Fabrication and Application of A Simulating Device for Magnetic Drug Targeting and Release[J]. Chinese Journal of Applied Chemistry, ;2012, 29(1): 69-74. doi: 10.3724/SP.J.1095.2012.00078 shu

Fabrication and Application of A Simulating Device for Magnetic Drug Targeting and Release

1.
a Department of Applied Chemistry, College of Science, Chongqing Jiaotong University, Chongqing 400074, China;
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b State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China

Corresponding author: PAN Dengke,
Received Date: 28 February 2011
Available Online: 14 April 2011
Fund Project: 国家自然科学基金(B07004) (B07004)重庆自然科学基金(2007BB4394)资助项目 (2007BB4394)

A simulating device for magnetic drug targeting and release in human body was fabricated by using peristaltic pump,NdFeB magnet,polyethylene pipe,water bath and glass tube.The device was used to test the magnetic drug targeting and release property of a model magnetic drug-carried particles Fe₃O₄@DFUR-LDH(DFUR:doxifluridine,LDH:layered double hydroxide).It is found that the retention of the Fe₃O₄@DFUR-LDH particles can be achieved to 85.3%,and it decreases as increasing the distance between the magnet and Fe₃O₄@DFUR-LDH particles in this device.Increasing the velocity of the release medium can also lead to the decrease of the retention of Fe₃O₄@DFUR-LDH particles.It also reveals that the drug release rate of Fe₃O₄@DFUR-LDH particles increases gradually as increasing the velocity of the releasing medium in this device.By modifying the pipe system,the situation when the drug was continuously consumed in the human body was also simulated.This device can not only simulate the magnetic targeting,but also analyze the drug release behavior of the magnetic drug-carried particles retained in a special site with the use of a magnetic field,thus providing an effective way to analyze the properties of magnetic drug-carried particles before submitting to the clinical study.
- magnetic drug targeting,
- device design,
- simulation,
- drug release,
- doxifluridine
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