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Citation: HE Huaizhen, ZHAN Yingzhuan, ZHANG Jie, WANG Tao. Synthesis and Anti-tumor Activities of Lactone Ring-Opened Taspine Coumarin Ester Fluorescent Derivatives[J]. Chinese Journal of Applied Chemistry, ;2012, 29(1): 75-79. doi: 10.3724/SP.J.1095.2012.00054 shu

Synthesis and Anti-tumor Activities of Lactone Ring-Opened Taspine Coumarin Ester Fluorescent Derivatives

1.
School of Medicine, Xi'an Jiaotong University, Xi'an 710061

Corresponding author: HE Huaizhen,
Received Date: 21 February 2011
Available Online: 7 April 2011
Fund Project:

Using isovanillin as the starting material,the lactone ring-opened taspine derivative(compound 8) was obtained via bromination,benzylation,oxidation,Ulmman reaction and catalytic hydrogenation.Based on this,we designed and synthesized two novel lactone ring-opened taspine coumarin ester fluorescent derivatives with substituted coumarin(compounds 9a and 9b).The structures of the target compounds were characterized by means of IR,¹H NMR and MS.The fluorescence and the anti-tumor activities of the target compounds were preliminarily examined.
- taspine,
- coumarin,
- fluorescence,
- anti-tumor activity
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