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Citation: SHENG Shihou, YU Huiqiu, LIU Tongjun, LIU Shi, ZHENG Yonghui, HU Xiuli, SONG Xiangfu. Anti-tumor Activity of Biodegradable Polymer-Paclitaxel Conjugate Micelles on H22 Liver Cancer Mice Models[J]. Chinese Journal of Applied Chemistry, ;2011, 28(11): 1280-1285. doi: 10.3724/SP.J.1095.2011.00734 shu

Anti-tumor Activity of Biodegradable Polymer-Paclitaxel Conjugate Micelles on H22 Liver Cancer Mice Models

1.
a China-Japan Union Hospital of Jilin University, Changchun 130033;
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b State Key Laboratory of Polymer Physics and Chemistry, Chinese Academy of Sciences, Changchun 130022;
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c Institute of Public Health, Jilin University, Changchun 130033

Corresponding author: LIU Tongjun,
Received Date: 10 July 2011
Available Online: 25 September 2011
Fund Project: 国家自然科学基金(21004062) (21004062)吉林省科技厅(200705110)资助项目 (200705110)

The anti-tumor effects of the polymer-paclitaxel conjugate micelles and free paclitaxel on H22 liver cancer bearing mice were evaluated. After 10 days drug administration, the tumor volume inhibition rates(VIR) of free paclitaxel group, polymer-paclitaxel conjugate micelles group at doses of 3 mg/kg, and the micelles group at doses of 6 mg/kg are 22%, 49%, and 67%, respectively. In addition, the tumor weight inhibition rates(WIR) are 29%, 45%, and 47%, respectively. Protein expression results show that paclitaxel micelles group has higher expression of p53 and lower expression of bcl-2. All these results indicate that the anti-tumor effect of polymer-paclitaxel conjugate micelles is stronger than free paclitaxel.
- H22 liver cancer mice,
- paclitaxel,
- nano-micelles,
- conjugate drug
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