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Citation: LI Yang, NING Zhigang, TAN Ying, SUN Shumiao, WANG Pixin. Preparation and Drug-release Properties of Ibuprofen-loaded and Fluorescein-labeled Starch-based Nanospheres[J]. Chinese Journal of Applied Chemistry, ;2011, 28(10): 1114-1121. doi: 10.3724/SP.J.1095.2011.00699 shu

Preparation and Drug-release Properties of Ibuprofen-loaded and Fluorescein-labeled Starch-based Nanospheres

LI Yang ^a ,
NING Zhigang ^a ,
TAN Ying ^b ,
SUN Shumiao ^a ,
WANG Pixin ^b,,

1.
a School of Chemistry and Life Science, Changchun University of Technology, Changchun;
2.
b Key Laboratory of Ecomaterial Polymers, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022

Corresponding author: WANG Pixin,
Received Date: 24 November 2010
Available Online: 18 January 2011
Fund Project: 国家自然科学基金资助项目(21004065,51073153) (21004065,51073153)

Starch was firstly acylated by acetic anhydride,fluorescein isothiocyanate(FITC) was then covalently attached onto the starch acetate.And the fluorescein-labeled starch acetate could self-assemble to form uniform nanospheres encapsulated with ibuprofen.The controlled-release properties of obtained ibuprofen-loaded fluorescein-labeled starch nanospheres were investigated in details.The amounts of drugloading and release rate could be tuned by changing the amounts of fluorescein-labeled starch acetate,ibuprofen and volume ratio of acetone to water.The results showed that up to 69.5% of the drug could be encapsulated when the amounts of fluorescein-labeled starch acetate and ibuprofen were 200 mg and 60 mg,and the volumes of water and acetone were 50 mL and 20 mL,respectively.The drug release rate in vitro of these nanospheres was 62.7% at 48 h.Moreover,the release process in vitro of the drug-loaded nanospheres was characterized by scanning electron microscope(SEM) and confocal laser scanning microscope(CLSM).
- starch,
- fluorescein nanosphere,
- ibuprofen,
- encapsulation efficiency,
- drug release
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