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Citation: LI Jing, BI Hongyan, DU Baotong, SUN Yanzhi, ZHANG Honglin. Bacteriostatic Activities of Metal-Tet Complexes Studied by Microcalorimetry[J]. Chinese Journal of Applied Chemistry, ;2011, 28(8): 897-900. doi: 10.3724/SP.J.1095.2011.00485 shu

Bacteriostatic Activities of Metal-Tet Complexes Studied by Microcalorimetry

1.
College of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165

Corresponding author: ZHANG Honglin,
Received Date: 19 August 2010
Available Online: 29 October 2010

Four new metal complexes were synthesized by the reaction of tetrandrine(Tet,extracted from Stephania tetrandra S.Moore) with M(NO₃)₂·3H₂O(M=Cu,Zn,Co,Ni) in ethanol and characterized by FT-IR and UV.The power-time curves of bacteriostatic activities of Tet,its four metal complexes and metal nitrates with different concentrations(c) were determined by the titration microcalorimetry method.The growth rate constants(μ) of E.coli were calculated using logistic equation.The relationships of μ-c for the investigated systems were established and the inhibitory concentrations were optimized.By comparing their optimized inhibitory concentrations,it was found that the bacteriostatic activities of the four metal-Tet complexes on E.coli were superior to those of M(NO₃)₂·3H₂O and Tet.
- tetrandrine,
- metal complexes,
- microcalorimetry,
- E.coli,
- the best inhibitory concentration
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