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Citation: REN Yanyan, JIN Gendi, HU Xiaoya. Electrochemical Determination of Erythromycin Ethylsuccinate Using a Carbon Paste Electrode[J]. Chinese Journal of Applied Chemistry, ;2011, 28(6): 704-708. doi: 10.3724/SP.J.1095.2011.00431 shu

Electrochemical Determination of Erythromycin Ethylsuccinate Using a Carbon Paste Electrode

1.
College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002

Corresponding author: HU Xiaoya,
Received Date: 29 July 2010
Available Online: 15 October 2010
Fund Project: 国家自然科学基金(20875081,21075107)资助项目 (20875081,21075107)

A carbon paste electrode used as the working electrode,the electrochemical behavior of erythromycin ethylsuccinate(EEs) was investigated by cyclic voltammetry(CV) and differential pulse voltammetry(DPV),a novel method was proposed for the determination of EEs.The results showed two irreversible anodic peaks appeared at 0.83 V and 0.97 V,respectively in 0.1 mol/L PBS buffer solution(pH=8.0),indicating that there were two-step irreversible oxidations.Quantitative measurements by chronoamperometry(I-t) showed that the peak currents were proportional to erythromycin ethylsuccinate concentration in the range of 2.0×10^-7~2.8×10^-6 and 2.8×10^-6~3.1×10^-5 mol/L,respectively,with the detection limit(S/N=3) of 1.0×10^-7 mol/L.The recovery was in the range of 95.0%~98.8% with a RSD of 3.4%(n=3).The method showed a high selectivity and sensitivity,and could be used for the determination of EEs in the drugs with satisfactory result.
- erythromycin ethylsuccinate,
- carbon paste electrode,
- electrochemical determination,
- chronoamperometry
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