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Citation: CHEN Qifan, ZHANG Huidong, GONG Shengchen. Synthesis of 4-Substituted-2-Amino-pyrimidines[J]. Chinese Journal of Applied Chemistry, ;2011, 28(4): 382-386. doi: 10.3724/SP.J.1095.2011.00372 shu

Synthesis of 4-Substituted-2-Amino-pyrimidines

1.
Experiment Center, Eastern Liaoning University, Dandong 118003

Corresponding author: CHEN Qifan,
Received Date: 25 June 2010
Available Online: 28 September 2010
Fund Project: "十五"国家科技攻关计划(2004BA304B) (2004BA304B)

N,N-Dimethylformamide-dimethyl acetal(DMF-DMA) was refluxed with the corresponding aromatic or heterocyclic compounds to prepare the intermediates 3-(dimethylamino)-1-(substituted) prop-2-en-1-one with a yield of 71.2%~85.2%.By refluxing the obtained intermediates with guanidine hydrochloride in ethanol and in the presence of sodium ethoxide,fourteen 4-substituted-2-amino-pyrimidines were obtained in good yield of 66.6%~86.1%.All the products were confirmed by NMR,mass spectrometry,and elemental analysis.
- substituted-amino-pyrimidines,
- synthesis,
- characterization
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