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Citation: WANG Rulin, JIANG Hongyan, QIN Shuzhu, WANG Peng. Inclusions of Lornoxicam by β-Cyclodextrin and Its Derivatives[J]. Chinese Journal of Applied Chemistry, ;2011, 28(4): 421-425. doi: 10.3724/SP.J.1095.2011.00358 shu

Inclusions of Lornoxicam by β-Cyclodextrin and Its Derivatives

1.
Chemistry Department of Shanxi Medical University, Taiyuan 030001

Corresponding author: WANG Rulin,
Received Date: 22 June 2010
Available Online: 15 October 2010
Fund Project: 山西省科技厅自然科学基金(20051029)资助项目 (20051029)

The inclusions of lornoxicam(LX) by β-cyclodextrin(β-CD),hydroxypropyl-β-cyclodextrin(HP-β-CD),and sulfobutyl ether-β-cyclodextrin(SBE-β-CD) were studied by fluorescence spectroscopy,differential scanning calorimetry(DSC) and NMR at different pH and temperature.The results showed that the 1:1 inclusion compounds were formed between lornoxicam and CDs.Based on the formation constants,the interactions between lornoxicam and the three CDs follow an order of SBE-β-CD >HP-β-CD >β-CD.
- lornoxicam,
- β-cyclodextrin,
- fluorescence spectroscopy,
- DSC,
- NMR
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