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Citation: ZHONG Guiyun, SUN Lijuan. Synthesis and Biological Activity Study of Ionic Organotin Compounds[J]. Chinese Journal of Applied Chemistry, ;2011, 28(4): 387-393. doi: 10.3724/SP.J.1095.2011.00347 shu

Synthesis and Biological Activity Study of Ionic Organotin Compounds

ZHONG Guiyun ^b,, ,
SUN Lijuan ^a

1.
a Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071;
2.
b Department of Matiarals Technology, Jiangmen Polytechnic, Jiangmen 529090

Corresponding author: ZHONG Guiyun,
Received Date: 17 June 2010
Available Online: 27 September 2010
Fund Project: 国家自然科学基金(20372035)资助项目 (20372035)

A series of ionic organotin(Ⅳ) complexes with general formula [HNR₃][(PhCH2)3Sn(μ²-SCH2COO)Cl]、[HNR₃][(Ph₃Sn)₃(O₂CCH₂CO₂)₂]·CH₃CH₂OH and [HNR₃][MeCy₂ClSnO₂CCH₂-CO₂SnClCy₂Me] were synthesized by the reaction of organic acid with organotin halide in the presence of an organic base.The results of the anti-tumor,bactericidal and acaricidal activity show that some complexes have good biological activity.The inhibition rate of [HNR₃][(Ph₃Sn)₃(O₂CCH₂CO₂)₂]·CH₃CH₂OH and [HNR₃][MeCy₂ClSnO₂CCH₂-CO₂SnClCy₂Me] complexes for A-549,HCT-8 and Bel-7402 was about 90%,the mortality rate of [HNR₃][MeCy₂ClSnO₂CCH₂-CO₂SnClCy₂Me] complexes for Gibberella zeae,Alternaria solani,Phomopsis asparagi,Physalospora piricola,Cercospora arachidicol was 100%,the mortality rate of [HNR₃][MeCy₂ClSnO₂CCH₂-CO₂SnClCy₂Me] complexes for acaricidal activity was more than 90%.
- ionic organotin,
- biological activity,
- anti-tumor activity,
- bactericidal activity,
- sterilization activity
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