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Citation: BU Xiaoyang, WU Ming, ZHOU Jiahong, YANG Xiaodi, LU Tianhong, LI Huihui. Spectrometric Study on the Interactions Between Organic Pesticide Pollutants and DNA[J]. Chinese Journal of Applied Chemistry, ;2011, 28(4): 458-463. doi: 10.3724/SP.J.1095.2011.00326 shu

Spectrometric Study on the Interactions Between Organic Pesticide Pollutants and DNA

1.
a Jiangsu Key Laboratory of Biofunctional Materials, Department of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097;
2.
b Analysis and Test Center, Nanjing Normal University, Nanjing 210097

Corresponding author: LI Huihui,
Received Date: 4 June 2010
Available Online: 30 September 2010
Fund Project: 国家自然科学基金(20902048,20875047) (20902048,20875047)江苏省高校自然科学基金(09KJB150004) (09KJB150004)江苏省科技重大项目-江苏省生物医药材料测试服务平台开放基金(BM2007132) (BM2007132)生命分析化学教育部重点实验室开放基金(KLACLS07006)资助项目 (KLACLS07006)

The interactions of organic pesticide pollutants including,dichlorvos(DDVP),omethoate(OME),dimethoate(DIM) and plenazine-1-carboxylic acid(PCA),with the telomere DNA were investigated with ultraviolet spectroscopy,fluorescence spectroscopy and circular dichroism(CD).The results indicated that the organic pesticide pollutants interact with DNA mainly through the intercalative mode.The apparent binding constants of organic pesticides with DNA were calculated to be 1.17×10⁶,1.48×10⁶,4.52×10⁵,and 1.80×10⁶ L/mol,respectively.The apparent binding constants revealed that the order of the relative binding affinity is PCA >DIM >DDVP >OME.The CD measurement indicated that these organic pesticide pollutants caused instability of the structure of the duplex DNA by weakening the π-π stacking of DNA base pairs.To some extent,it also affected the secondary structure of DNA,leading to the relaxing of the twin helix structure.
- organic pesticide pollutants,
- deoxyribonucleic acid,
- interaction,
- intercalative mode
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