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Citation: CHEN Ming-Li, REN Jin-Song. Parallel G-quadruplex Recognition and Stabilization by Oxazine750[J]. Chinese Journal of Applied Chemistry, ;2010, 27(9): 1061-1064. doi: 10.3724/SP.J.1095.2010.90853 shu

Parallel G-quadruplex Recognition and Stabilization by Oxazine750

Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022

Received Date: 18 December 2009
Revised Date: 27 February 2010

The bindings of small molecular oxazine 750 to d[TG₄T]₄,d[G₄T₄G₄]₂ and c-myc sequences was characterized by means of circular dichroism,thermal denaturation,and so on. Oxazine 750 was found to bind preferentially and strongly to parallel G-quadruplex. It can effectively stabilize the parallel G-quadruplex and destabilize the antiparallel G-quadruplex. The melting temperature of d[TG₄T]₄ or c-myc is increased by about 11℃ or 40℃ by oxazine 750,respectively. Under the same condition,oxazine 750 decreased the melting temperature of d[G₄T₄G₄]₂ by about 8℃.
- G-quadruplex,
- small molecular,
- competition dialysis
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